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ASIMIA^TM (paroxetine mesylate) is an orally administered psychotropic drug with a chemical structure related to paroxetine hydrochloride (Paxil®). It is the mesylate salt of a phenylpiperidine compound identified chemically as (-)-trans -4R- (4' - fluorophenyl) - 3S - [(3', 4-methylenedioxyphenoxy) methyl] piperidine mesylate and has the empirical formula of C ₁₉H₂₀FNO₃ CH₃SO₃H. The molecular weight is 425.5 (329.4 as free base). The structural formula is:

Paroxetine mesylate is an odorless, off-white powder, having a melting point range of 147° to 150°C and a solubility of more than 1 g/mL in water.

Each oval, film coated tablet contains paroxetine mesylate equivalent to paroxetine as follows: 10 mg (white); 20 mg (scored, dark orange); 30 mg (yellow); 40 mg (rose). Inactive ingredients consist of dibasic calcium phosphate, hydroxypropyl methylcellulose, hydroxypropylcellulose, magnesium stearate, sodium starch glycolate, titanium dioxide, ferric oxide red (C.I. 77491) (20-mg, and 40-mg only) and ferric oxide yellow (C.I. 77492) (20-mg, 30-mg and 40-mg only).

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.