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Chronic overdosage may result in signs/symptoms of hypercorticism [see WARNINGS AND PRECAUTIONS]. Because of low systemic bioavailability and an absence of acute drug-related systemic findings in clinical studies, acute overdose is unlikely to require any treatment other than observation. Single daily doses as high as 1200 mcg per day for 28 days were well tolerated and did not cause a significant reduction in plasma cortisol AUC (94% of placebo AUC). Single oral doses up to 8000 mcg have been studied on human volunteers with no adverse reactions reported.
ASMANEX TWISTHALER (mometasone furoate) therapy is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.
ASMANEX TWISTHALER (mometasone furoate) is contraindicated in patients with known hypersensitivity to milk proteins or any ingredients of ASMANEX TWISTHALER. [see WARNINGS AND PRECAUTIONS and DESCRIPTION].
Last reviewed on RxList: 10/14/2010
This monograph has been modified to include the generic and brand name in many instances.
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