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Atridox

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There are several types of medications that are used to manage a variety of diseases involving the oral cavity (mouth) that are part of good dental care. The medications discussed in this article h"...

Atridox

ATRIDOX (doxycycline hyclate) ®
(doxycycline hyclate) 10% in the ATRIGEL® Delivery System for controlled release in subgingival application

Atridox

DRUG DESCRIPTION

The ATRIDOX (doxycycline hyclate) ® product is a subgingival controlled-release product composed of a two syringe mixing system. Syringe A contains 450 mg of the ATRIGEL® Delivery System, which is a bioabsorbable, flowable polymeric formulation composed of 36.7% poly(DLlactide) (PLA) dissolved in 63.3% N-methyl-2-pyrrolidone (NMP). Syringe B contains 50 mg of doxycycline hyclate which is equivalent to 42.5 mg doxycycline. The constituted product is a pale yellow to yellow viscous liquid with a concentration of 10% of doxycycline hyclate. Upon contact with the crevicular fluid, the liquid product solidifies and then allows for controlled release of drug for a period of 7 days. Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline.

The structural formula of doxycycline hyclate is:

ATRIDOX® (doxycycline hyclate)  Structural Formula Illustration

Empirical Formula: (C22H24N2O8•HCI)2•C2H6O•H2O

What are the precautions when taking doxycycline hyclate (Atridox)?

Before using doxycycline gel, tell your dentist or pharmacist if you are allergic to it; or to other tetracyclines; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your dentist or pharmacist your medical history, especially of: past/current fungal infections of mouth/vagina (e.g., thrush, yeast infection).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Caution is advised when using this drug in children younger than 8 years because they may be more likely to develop permanent...

Read All Potential Precautions of Atridox »

Last reviewed on RxList: 4/11/2011
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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