"Introduction to dental medications
There are several types of medications that are used to manage a variety of diseases involving the oral cavity (mouth) that are part of good dental care. The medications discussed in this article h"...
ATRIDOX (doxycycline hyclate) ®
(doxycycline hyclate) 10% in the ATRIGEL® Delivery System for controlled release in subgingival application
The ATRIDOX (doxycycline hyclate) ® product is a subgingival controlled-release product composed of a two syringe mixing system. Syringe A contains 450 mg of the ATRIGEL® Delivery System, which is a bioabsorbable, flowable polymeric formulation composed of 36.7% poly(DLlactide) (PLA) dissolved in 63.3% N-methyl-2-pyrrolidone (NMP). Syringe B contains 50 mg of doxycycline hyclate which is equivalent to 42.5 mg doxycycline. The constituted product is a pale yellow to yellow viscous liquid with a concentration of 10% of doxycycline hyclate. Upon contact with the crevicular fluid, the liquid product solidifies and then allows for controlled release of drug for a period of 7 days. Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline.
The structural formula of doxycycline hyclate is:
Empirical Formula: (C22H24N2O8•HCI)2•C2H6O•H2O
Last reviewed on RxList: 4/11/2011
This monograph has been modified to include the generic and brand name in many instances.
Additional Atridox Information
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