Gingivitis, also generally called gum disease or periodontal disease,
describes the events that begin with bacterial growth in your mouth and may
Gingivitis (gum inflammation) usually precedes periodontitis (gum disease). However, it is important to know that not all gingivitis progresses to periodontitis.
In the early stage of gingivitis, bacteria in plaque build up, causes the gums to become inflamed (red and swollen) and often easily bleed during tooth brushing. Although the gums may be irritated, the teeth are still firmly planted in their sockets. No irreversible bone or other tissue damage has occurred at this stage.
When gingivitis is left untreated, it can advance to periodontitis. ...
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In clinical trials involving a total of 1436 patients, adverse experiences from all causalities were monitored across treatment groups.
In the Circulatory System category, 10 subjects (1.6%) in the ATRIDOX (doxycycline hyclate) ® group were reported as having “unspecified essential hypertension.” Only 1 subject (0.2%) in the Vehicle group, and none in the Scaling and Root Planing or Oral Hygiene groups were reported to have “unspecified essential hypertension.” In all cases, the event occurred anywhere from 13 to 134 days post treatment. There is no known association of oral administration of doxycycline with essential hypertension.
Two patients in the polymer vehicle group and none in the ATRIDOX (doxycycline hyclate) ® group (0.2% for both groups combined) reported adverse events consistent with a localized allergic response.
Sex, age, race and smoking status did not appear to be correlated with adverse events.
The following table lists the incidence of treatment-emergent adverse events from all causalities, across all treatment groups, occurring in ≥ 1% of the entire study population.
| Body System Verbatim Terms | Doxycycline n=609 |
Vehicle n=413 |
OH n=204 |
SRP n=210 |
| Circulatory | ||||
| High blood pressure | 1.60% | 0.20% | 0.00% | 0.00% |
| Digestive | ||||
| Gum discomfort, pain or soreness; loss of attachment; increased pocket depth | 18.10% | 23.00% | 20.10% | 21.00% |
| Toothache, pressure sensitivity | 14.30% | 14.30% | 10.30% | 18.10% |
| Periodontal abscess, exudate, infection, drainage, extreme mobility, suppuration | 9.90% | 10.90% | 10.30% | 8.60% |
| Thermal tooth sensitivity | 7.70% | 8.50% | 4.40% | 6.70% |
| Gum inflammation, swelling, sensitivity | 4.10% | 5.80% | 5.40% | 5.70% |
| Soft tissue erythema, sore mouth, unspecified pain | 4.30% | 5.30% | 2.70% | 6.20% |
| Indigestion, upset stomach, stomachache | 3.60% | 4.10% | 2.90% | 3.80% |
| Diarrhea | 3.30% | 2.40% | 1.00% | 1.00% |
| Tooth mobility, bone loss | 2.00% | 0.70% | 0.50% | 2.40% |
| Periapical abscess, lesion | 1.50% | 1.90% | 1.00% | 0.50% |
| Aphthous ulcer, canker sores | 0.70% | 1.70% | 1.00% | 1.40% |
| Fistula | 0.80% | 1.50% | 1.50% | 1.00% |
| Endodontic abscess, pulpitis | 1.50% | 1.50% | 0.00% | 0.50% |
| Jaw pain | 1.10% | 0.50% | 1.00% | 1.90% |
| Tooth loss | 0.80% | 1.50% | 1.50% | 0.00% |
| Bleeding gums | 1.00% | 0.70% | 0.00% | 2.40% |
| Genitourinary | ||||
| Premenstrual tension syndrome | 4.40% | 3.10% | 2.50% | 3.30% |
| Ill-Defined Conditions | ||||
| Headache | 27.30% | 28.10% | 23.50% | 23.80% |
| Cough | 3.60% | 6.10% | 2.90% | 2.40% |
| Sleeplessness | 3.40% | 1.50% | 2.00% | 2.90% |
| Body aches, soreness | 1.60% | 1.20% | 1.50% | 1.40% |
| Nausea and vomiting | 1.80% | 0.70% | 2.50% | 0.50% |
| Fever | 1.00% | 1.90% | 1.00% | 1.90% |
| Injury & Poisoning | ||||
| Broken tooth | 5.10% | 4.10% | 4.90% | 5.70% |
| Mental | ||||
| Tension headache | 1.80% | 0.70% | 0.00% | 1.00% |
| Musculoskeletal | ||||
| Muscle aches | 6.40% | 4.60% | 4.90% | 3.30% |
| Backache | 3.60% | 5.30% | 2.50% | 6.20% |
| Pain in arms or legs | 1.50% | 2.20% | 2.00% | 2.40% |
| Lower back pain | 1.60% | 1.70% | 0.50% | 2.90% |
| Neck pain | 1.30% | 1.70% | 1.00% | 1.90% |
| Shoulder pain | 1.00% | 1.00% | 1.50% | 1.00% |
| Nervous System | ||||
| Ear infection | 1.60% | 1.90% | 2.00% | 0.00% |
| Respiratory | ||||
| Common cold | 25.50% | 25.20% | 18.10% | 16.70% |
| Flu, respiratory | 6.10% | 9.00% | 3.90% | 6.70% |
| Stuffy head, post nasal drip, congestion | 5.60% | 7.70% | 2.90% | 4.80% |
| Sore throat | 5.70% | 6.50% | 2.00% | 3.30% |
| Sinus infection | 5.30% | 2.70% | 1.00% | 1.90% |
| Flu | 2.80% | 2.90% | 2.90% | 3.30% |
| Bronchitis | 2.30% | 1.90% | 1.50% | 1.00% |
| Allergies | 1.00% | 1.00% | 1.00% | 1.90% |
| Skin & Subcutaneous Tissue | ||||
| Skin infection or inflammation | 1.30% | 1.00% | 1.00% | 1.00% |
No information provided.
Last reviewed on RxList: 4/11/2011
This monograph has been modified to include the generic and brand name in many instances.
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