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Atridox

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Atridox

Atridox

Atridox Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Atridox (doxycycline hyclate) is an antibiotic used to treat chronic periodontitis. Common side effects of Atridox include gum discomfort, pain, soreness, and toothache.

Talk to your doctor or dentist about your individual dosage recommendation. Rifampin and rifabutin may interact with Atridox. Tell your doctor or dentist all medications you take. Atridox can cause tooth discoloration if used in children and infants during tooth development. Do not use Atridox if you are pregnant or breastfeeding.

Our Atridox (doxycycline hyclate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Atridox Overview - Patient Information: Side Effects

SIDE EFFECTS: Gum discomfort/pain/soreness or toothache may occur. If any of these effects persist or worsen, tell your dentist or pharmacist promptly.

Remember that your dentist has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your dentist immediately if any of these unlikely but serious side effects occur: tooth loosening, jaw pain, sunburn.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Atridox (Doxycycline Hyclate)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Atridox FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

In clinical trials involving a total of 1436 patients, adverse experiences from all causalities were monitored across treatment groups.

In the Circulatory System category, 10 subjects (1.6%) in the ATRIDOX (doxycycline hyclate) ® group were reported as having “unspecified essential hypertension.” Only 1 subject (0.2%) in the Vehicle group, and none in the Scaling and Root Planing or Oral Hygiene groups were reported to have “unspecified essential hypertension.” In all cases, the event occurred anywhere from 13 to 134 days post treatment. There is no known association of oral administration of doxycycline with essential hypertension.

Two patients in the polymer vehicle group and none in the ATRIDOX (doxycycline hyclate) ® group (0.2% for both groups combined) reported adverse events consistent with a localized allergic response.

Sex, age, race and smoking status did not appear to be correlated with adverse events.

The following table lists the incidence of treatment-emergent adverse events from all causalities, across all treatment groups, occurring in ≥ 1% of the entire study population.

Body System Verbatim Terms Doxycycline
n=609
Vehicle
n=413
OH
n=204
SRP
n=210
Circulatory
  High blood pressure 1.60% 0.20% 0.00% 0.00%
Digestive
  Gum discomfort, pain or soreness; loss of attachment; increased pocket depth 18.10% 23.00% 20.10% 21.00%
  Toothache, pressure sensitivity 14.30% 14.30% 10.30% 18.10%
  Periodontal abscess, exudate, infection, drainage, extreme mobility, suppuration 9.90% 10.90% 10.30% 8.60%
  Thermal tooth sensitivity 7.70% 8.50% 4.40% 6.70%
  Gum inflammation, swelling, sensitivity 4.10% 5.80% 5.40% 5.70%
  Soft tissue erythema, sore mouth, unspecified pain 4.30% 5.30% 2.70% 6.20%
  Indigestion, upset stomach, stomachache 3.60% 4.10% 2.90% 3.80%
  Diarrhea 3.30% 2.40% 1.00% 1.00%
  Tooth mobility, bone loss 2.00% 0.70% 0.50% 2.40%
  Periapical abscess, lesion 1.50% 1.90% 1.00% 0.50%
  Aphthous ulcer, canker sores 0.70% 1.70% 1.00% 1.40%
  Fistula 0.80% 1.50% 1.50% 1.00%
  Endodontic abscess, pulpitis 1.50% 1.50% 0.00% 0.50%
  Jaw pain 1.10% 0.50% 1.00% 1.90%
  Tooth loss 0.80% 1.50% 1.50% 0.00%
  Bleeding gums 1.00% 0.70% 0.00% 2.40%
Genitourinary
  Premenstrual tension syndrome 4.40% 3.10% 2.50% 3.30%
Ill-Defined Conditions
  Headache 27.30% 28.10% 23.50% 23.80%
  Cough 3.60% 6.10% 2.90% 2.40%
  Sleeplessness 3.40% 1.50% 2.00% 2.90%
  Body aches, soreness 1.60% 1.20% 1.50% 1.40%
  Nausea and vomiting 1.80% 0.70% 2.50% 0.50%
  Fever 1.00% 1.90% 1.00% 1.90%
Injury & Poisoning
  Broken tooth 5.10% 4.10% 4.90% 5.70%
Mental
  Tension headache 1.80% 0.70% 0.00% 1.00%
Musculoskeletal
  Muscle aches 6.40% 4.60% 4.90% 3.30%
  Backache 3.60% 5.30% 2.50% 6.20%
  Pain in arms or legs 1.50% 2.20% 2.00% 2.40%
  Lower back pain 1.60% 1.70% 0.50% 2.90%
  Neck pain 1.30% 1.70% 1.00% 1.90%
  Shoulder pain 1.00% 1.00% 1.50% 1.00%
Nervous System
  Ear infection 1.60% 1.90% 2.00% 0.00%
Respiratory 
  Common cold 25.50% 25.20% 18.10% 16.70%
  Flu, respiratory 6.10% 9.00% 3.90% 6.70%
  Stuffy head, post nasal drip, congestion 5.60% 7.70% 2.90% 4.80%
  Sore throat 5.70% 6.50% 2.00% 3.30%
  Sinus infection 5.30% 2.70% 1.00% 1.90%
  Flu 2.80% 2.90% 2.90% 3.30%
  Bronchitis 2.30% 1.90% 1.50% 1.00%
  Allergies 1.00% 1.00% 1.00% 1.90%
Skin & Subcutaneous Tissue
  Skin infection or inflammation 1.30% 1.00% 1.00% 1.00%

Read the entire FDA prescribing information for Atridox (Doxycycline Hyclate) »

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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