July 24, 2016
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Atrovent Nasal Spray

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Atrovent Nasal Spray

Atrovent®
(ipratropium bromide) Nasal Spray




DRUG DESCRIPTION

The active ingredient in ATROVENT Nasal Spray is ipratropium bromide (as the monohydrate). It is an anticholinergic agent chemically described as 8-azoniabicyclo[3.2.1] octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide monohydrate, (3-endo, 8-syn)-: a synthetic quaternary ammonium compound, chemically related to atropine. The structural formula is:

Atrovent® (ipratropium bromide) Structural Formula Illustration

C20H30BrNO3•H2O     ipratropium bromide      Mol. Wt. 430.4

Ipratropium bromide is a white to off-white crystalline substance, freely soluble in water and methanol, sparingly soluble in ethanol, and insoluble in non-polar media. In aqueous solution, it exists in an ionized state as a quaternary ammonium compound.

ATROVENT Nasal Spray 0.06% is a metered-dose, manual pump spray unit which delivers 42 mcg ipratropium bromide (on an anhydrous basis) per spray (70 μL) in an isotonic aqueous solution, pH-adjusted to 4.7 with hydrochloric acid and/or sodium hydroxide (if needed). It also contains benzalkonium chloride, edetate disodium, sodium chloride, and purified water. Each bottle contains 165 sprays.

What are the possible side effects of ipratropium nasal (Atrovent Nasal)?

Stop using ipratropium nasal and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a fast, pounding heartbeat.

Less serious side effects may include:

  • headache;
  • dry nose;
  • nosebleeds; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Atrovent Nasal Spray »

What are the precautions when taking ipratropium bromide nasal spray (Atrovent Nasal Spray)?

Before using ipratropium, tell your doctor or pharmacist if you are allergic to it or to tiotropium; or to atropine or other belladonna-type drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), difficulty urinating (for example, due to enlarged prostate).

Although unlikely, this drug may make you dizzy or cause blurred vision or other vision changes. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities...

Read All Potential Precautions of Atrovent Nasal Spray »

Last reviewed on RxList: 7/8/2016
This monograph has been modified to include the generic and brand name in many instances.

Atrovent Nasal Spray - User Reviews

Atrovent Nasal Spray User Reviews

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Here is a collection of user reviews for the medication Atrovent Nasal Spray sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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