March 28, 2017
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Atrovent Nasal Spray

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Atrovent Nasal Spray




Overdosage
Contraindications

OVERDOSE

Acute overdosage by intranasal administration is unlikely since ipratropium bromide is not well absorbed systemically after intranasal or oral administration. Following administration of a 20 mg oral dose (equivalent to ingesting more than two bottles of Atrovent® (ipratropium bromide) Nasal Spray 0.06%) to 10 male volunteers, no change in heart rate or blood pressure was noted. Following a 2 mg intravenous infusion over 15 minutes to the same 10 male volunteers, plasma ipratropium concentrations of 22-45 ng/mL were observed (>100 times the concentrations observed following intranasal administration). Following intravenous infusion these 10 volunteers had a mean increase of heart rate of 50 bpm and less than 20 mmHg change in systolic or diastolic blood pressure at the time of peak ipratropium levels.

CONTRAINDICATIONS

ATROVENT Nasal Spray 0.06% is contraindicated in patients with a history of hypersensitivity to atropine or its derivatives, or to any of the other ingredients.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 7/8/2016

Overdosage
Contraindications

Atrovent Nasal Spray - User Reviews

Atrovent Nasal Spray User Reviews

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