(measles virus) Vaccine Live
ATTENUVAX* (Measles Virus Vaccine Live) is a live virus vaccine for vaccination against measles (rubeola).
ATTENUVAX (measles virus vaccine live) is a sterile lyophilized preparation of a more attenuated line of measles virus derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture.
The growth medium for measles is Medium 199 (a buffered salt solution containing vitamins and amino acids and supplemented with fetal bovine serum) containing SPGA (sucrose, phosphate, glutamate, and human albumin) as stabilizer and neomycin.
The cells, virus pools, fetal bovine serum, and human albumin are all screened for the absence of adventitious agents. Human albumin is processed using the Cohn cold ethanol fractionation procedure.
The reconstituted vaccine is for subcutaneous administration. Each 0.5 mL dose contains not less than 1,000 TCID50 (tissue culture infectious doses) of measles virus. Each dose of the vaccine is calculated to contain sorbitol (14.5 mg), sodium phosphate, sucrose (1.9 mg), sodium chloride, hydrolyzed gelatin (14.5 mg), human albumin (0.3 mg), fetal bovine serum ( < 1 ppm), other buffer and media ingredients and approximately 25 mcg of neomycin. The product contains no preservative.
Before reconstitution, the lyophilized vaccine is a light yellow compact crystalline plug. ATTENUVAX (measles virus vaccine live) , when reconstituted as directed, is clear yellow.
* Registered trademark of MERCK & CO., Inc. COPYRIGHT © 1990, 1999 MERCK & CO., Inc. All rights reserved
Last reviewed on RxList: 12/2/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Attenuvax Information
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