February 24, 2017
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Aubagio

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Aubagio




Overdosage
Contraindications

OVERDOSE

There is no experience regarding teriflunomide overdose or intoxication in humans. Teriflunomide 70 mg daily up to 14 days was well tolerated by healthy subjects.

In the event of clinically significant overdose or toxicity, cholestyramine or activated charcoal is recommended to accelerate elimination [see WARNINGS AND PRECAUTIONS].

CONTRAINDICATIONS

AUBAGIO is contraindicated in/with:

  • Patients with severe hepatic impairment [see WARNINGS AND PRECAUTIONS].
  • Pregnant women and females of reproductive potential not using effective contraception. AUBAGIO may cause fetal harm [see WARNINGS AND PRECAUTIONS and Use In Specific Populations].
  • Patients with a history of a hypersensitivity reaction to teriflunomide, leflunomide, or to any of the inactive ingredients in AUBAGIO. Reactions have included anaphylaxis, angioedema, and serious skin reactions [see WARNINGS AND PRECAUTIONS].
  • Coadministration with leflunomide [see CLINICAL PHARMACOLOGY].
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/12/2016

Overdosage
Contraindications

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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