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Augmentin

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Augmentin

AUGMENTIN®
(amoxicillin/clavulanate potassium)

DRUG DESCRIPTION

AUGMENTIN is an oral antibacterial combination consisting of amoxicillin and the beta-lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid).

Amoxicillin is an analog of ampicillin, derived from the basic penicillin nucleus, 6-aminopenicillanic acid. The amoxicillin molecular formula is C16H19N3O5S•3H2O, and the molecular weight is 419.46. Chemically, amoxicillin is (2S,5R,6R)-6-[(R)-(-)-2-Amino-2-(phydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate and may be represented structurally as:

Amoxicillin Structural Formula Illustration

Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a beta-lactam structurally related to the penicillins and possesses the ability to inactivate some beta-lactamases by blocking the active sites of these enzymes. The clavulanate potassium molecular formula is C8H8KNO5, and the molecular weight is 237.25. Chemically, clavulanate potassium is potassium (Z)(2R,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]-heptane-2-carboxylate and may be represented structurally as:

Clavulanic acid Structural Formula Illustration

Inactive Ingredients
  • Tablets-Colloidal silicon dioxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide. Each tablet of amoxicillin/clavulanate potassium contains 0.63 mEq potassium.
  • Powder for Oral Suspension-Colloidal silicon dioxide, flavorings, xanthan gum, and one or more of the following: hypromellose, mannitol, silica gel, silicon dioxide, succinic acid,
  • Chewable Tablets-Colloidal silicon dioxide, flavorings, magnesium stearate, mannitol, and one or more of the following: D&C Yellow No. 10, FD&C Red No. 40, glycine, sodium saccharin, and aspartame. [see WARNINGS AND PRECAUTIONS]
    • Each 125-mg chewable tablet and each 5 mL of reconstituted 125/5 mL oral suspension of AUGMENTIN contains 0.16 mEq potassium
    • Each 250-mg chewable tablet and each 5 mL of reconstituted 250/5 mL oral suspension of AUGMENTIN contains 0.32 mEq potassium
    • Each 200-mg chewable tablet and each 5 mL of reconstituted 200/5 mL oral suspension of AUGMENTIN contains 0.14 mEq potassium
    • Each 400-mg chewable tablet and each 5 mL of reconstituted 400/5 mL oral suspension of AUGMENTIN contains 0.29 mEq potassium sodium saccharin, and aspartame. [see WARNINGS AND PRECAUTIONS]

What are the possible side effects of amoxicillin and clavulanate potassium (Augmentin, Augmentin ES-600, Augmentin XR)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or has blood in it;
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • easy bruising or bleeding;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • agitation,...

Read All Potential Side Effects and See Pictures of Augmentin »

Last reviewed on RxList: 2/4/2013
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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