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As with other plasma preparations, reactions manifested by fever, chills or indications of protein sensitivity may be observed with the administration of Autoplex® T, Anti-Inhibitor Coagulant Complex, Heat Treated. Signs and/or symptoms of high prekallikrein activity, such as changes in blood pressure or pulse rate may also be observed. It is advisable that appropriate medications be available for the treatment of acute allergic reactions or acute vasoactive reactions, should they occur.
A rate of infusion that is too rapid may cause headache, flushing, and changes in pulse rate and blood pressure. In such instances, stopping the infusion allows the symptoms to disappear promptly. With all but the most reactive individuals, infusion may be resumed at a slower rate.
Read the Autoplex-T (anti-inhibitor coagulant complex, heat treated) Side Effects Center for a complete guide to possible side effects
Since only limited data are available on the administration of highly activated prothrombin complex products together with antifibrinolytic agents such as epsilon-aminocaproic acid (EACA) or tranexamic acid,5 the concomitant use of Autoplex® T, Anti-Inhibitor Coagulant Complex, Heat Treated, with such agents is not recommended.
5. Mannucci PM, Federici F, Vigano S, et al: Multiple dental extractions with a new prothrombin complex concentrate in two patients with factor VIII inhibitors. Thromb Res 15:359-364, 1979
Read the Autoplex-T Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Autoplex-T Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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