"The American Academy of Pediatrics (AAP) confirms in a new report that epinephrine is the medication of choice for the first-aid treatment of anaphylaxis and updates a 2007 report on how it should be used most effectively.
"All other "...
Mechanism Of Action
Epinephrine acts on both alpha and beta-adrenergic receptors.
Through its action on alpha-adrenergic receptors, epinephrine lessens the vasodilation and increased vascular permeability that occurs during anaphylaxis, which can lead to loss of intravascular fluid volume and hypotension.
Epinephrine also alleviates pruritus, urticaria, and angioedema and may relieve gastrointestinal and genitourinary symptoms associated with anaphylaxis because of its relaxer effects on the smooth muscle of the stomach, intestine, uterus and urinary bladder.
When given subcutaneously or intramuscularly, epinephrine has a rapid onset and short duration of action.
Last reviewed on RxList: 1/3/2017
This monograph has been modified to include the generic and brand name in many instances.
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