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Auvi-Q Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/28/2016

Auvi-Q (epinephrine) Injection is a sympathomimetic catecholamine used in the emergency treatment of allergic reactions or anaphylaxis, which can be caused by stings or bites from insects (such as bees, wasps, hornets, yellow jackets, fire ants, and mosquitos), food, drugs, diagnostic testing substances, idiopathic (unknown) cause, or induced by exercise. Common side effects of Auvi-Q injection include:

  • anxiety
  • apprehensiveness
  • nervousness
  • restlessness
  • tremor or shakiness
  • weakness
  • dizziness
  • sweating
  • increased heart rate
  • heart palpitations
  • irregular heartbeat
  • pale skin (pallor)
  • nausea and vomiting
  • headache
  • difficulty breathing, and
  • injection site reactions (redness, bruising, bleeding, discoloration).

Tell your doctor if you have serious side effects of Auvi-Q injection such as arrhythmias, including fatal ventricular fibrillation.

If you are 66 pounds or heavier the recommended dosage of Auvi-Q is 0.3 mg, and 0.15 mg if you are 33 to 66 pounds. Auvi-Q should be used in addition to immediate medical care. Do not inject Auvi-Q intravenously, into the buttock or fingers, hands or feet. Although Auvi-Q contains sulfite you can still use Auvi-Q if you are sulfite sensitive. Caution should be used if you have heart disease, cardiac arrhythmias, coronary artery or organic heart disease, hypertension, hyperthyroidism, diabetes, and elderly individuals. Auvi-Q may interact with cardiac glycosides, diuretics, anti-arrhythmics, antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, antihistamines, beta-blockers, alpha blockers, or ergot alkaloids. Tell your doctor all medications you use. Caution should also be taken if you are pregnant or breastfeeding.

Our Auvi-Q (epinephrine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Auvi-Q FDA Prescribing Information: Side Effects
(Adverse Reactions)


Due to lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.

Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].

Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].

Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see WARNINGS AND PRECAUTIONS].

Angina may occur in patients with coronary artery disease [see WARNINGS AND PRECAUTIONS].

Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].

Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.

Injection of epinephrine into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection in the thigh [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Auvi-Q (Epinephrine Injection)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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