Avage (Tazarotene) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Avage

Wrinkles »

Wrinkles facts

Skin ages all over the body but much more so where there has been sun exposure. Changes brought on by sun damage (photoaging) include "dryness" (really roughness), sagginess, skin growths like keratoses ("liver spots"), and wrinkles.
Wrinkles in turn can be divided into two categories: fine surface lines and deep furrows. Wrinkle treatments are in general much more effective for fine lines. Deeper creases may require more aggressive techniques, such as plastic surgery.
Factors that promote wrinkling include smoking, skin type (people with light-colored skin and blue eyes are more susceptible to sun damage), heredity (some families wrinkle more), hairstyle (depending on how much skin is covered by hair and protected from the sun), dress (again, by determining which skin is exposed), and occupational and recreational sun exposure over the course of many years.

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AVAGE®
(tazarotene) Cream, 0.1%

FOR TOPICAL USE ONLY. NOT FOR OPHTHALMIC, ORAL, OR INTRAVAGINAL USE.

DRUG DESCRIPTION

AVAGE® (tazarotene) Cream is a white cream and contains the compound tazarotene; this formulation of tazarotene cream is also marketed for the treatment of plaque psoriasis and acne vulgaris as TAZORAC® (tazarotene) Cream, 0.1%. Tazarotene is a member of the acetylenic class of retinoids and is represented by the following structural formula:

AVAGE® (TAZAROTENE) Structural Formula Illustration

Formula: C₂₁H₂₁NO₂S Molecular Weight: 351.46

Chemical Name: Ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinate

Contains

Active: Tazarotene 0.1% (w/w)

Preservative: Benzyl alcohol 1.0% (w/w)

Inactives: Carbomer 934P, carbomer 1342, edetate disodium, medium chain triglycerides, mineral oil, purified water, sodium thiosulfate, sorbitan monooleate and sodium hydroxide to adjust the pH.

What are the possible side effects of tazarotene topical (Avage, Tazorac)?

Serious side effects are not likely to occur. Stop using tazarotene topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

You may experience some skin burning, warmth, stinging, tingling, itching, redness, swelling, dryness, peeling, or irritation while using tazarotene topical. If these side effects are excessive, talk to your doctor. You may need a lower dose or less frequent applications of tazarotene...

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What are the precautions when taking tazarotene (Avage)?

Before using tazarotene, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other skin conditions (e.g., eczema, sunburn, sun sensitivity).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Weather extremes such as wind or cold may also be irritating to the skin. Use a sunscreen (minimum SPF 15) daily, and wear protective clothing when outdoors. Wait until your skin has completely recovered from a sunburn before using this...

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Last reviewed on RxList: 10/8/2008
This monograph has been modified to include the generic and brand name in many instances.