Avalide (Irbesartan-Hydrochlorothiazide) Drug Information: Medication Guide and Patient Information

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May 25, 2012

Avalide

Stroke »

What is a stroke?

Brain cell function requires a constant delivery of oxygen and glucose from the bloodstream. A stroke, or cerebrovascular accident (CVA), occurs when blood supply to part of the brain is disrupted, causing brain cells to die. Blood flow can be compromised by a variety of mechanisms.

Blockage of an artery

Narrowing of the small arteries within the brain can cause a lacunar stroke, (lacune means "empty space"). Blockage of a single arteriole can affect a tiny area of brain causing that tissue to die (infarct).
Hardening of the arteries (atherosclerosis) leading to the brain. There are four major blood vessels that supply the brain with blood. The anterior circulation of the brain that controls most motor activity, sensation, thought, speech, and emotion is supplied by the carotid arteries. The posterior circulation, which supplies the brainstem and the cer...

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PATIENT INFORMATION

Pregnancy

Female patients of childbearing age should be told that use of drugs like AVALIDE during the second or third trimesters of pregnancy can cause serious problems in the fetus and infant including: low blood pressure, poor development of skull bones, kidney failure, and death. These effects have not occurred with drug exposure limited to the first trimester. Women using AVALIDE who become pregnant should notify their physician as soon as possible.

Symptomatic Hypotension

Patients using AVALIDE should be told that they may feel lightheaded, especially during the first days of use. Patients should inform their physician if they feel lightheaded or faint. If fainting occurs, the patient should stop using AVALIDE and contact the prescribing doctor.

Patients using AVALIDE should be told that getting dehydrated can lower their blood pressure too much and lead to lightheadedness and possible fainting. Dehydration may occur with excessive sweating, diarrhea, or vomiting and with not drinking enough liquids.

Last reviewed on RxList: 1/26/2012
This monograph has been modified to include the generic and brand name in many instances.