Avandia (Rosiglitazone Maleate) Drug Information: Overdosage and Contraindications

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May 25, 2012

Avandia

Diabetic Home Care and Monitoring »

What is diabetes?

Diabetes mellitus is a condition in which the body does not produce enough insulin or the insulin that is produced is ineffective. Insulin is produced and secreted by the pancreas and is needed for the proper storage and utilization of nutrients (glucose, proteins, and fat) by the cells of the body. Insulin allows nutrients to enter the cells of the body. For example, insulin allows cells to remove glucose from the blood, and the glucose is used to generate the energy that is necessary to fuel the activities of the cells. When insulin is absent or ineffective and the cells receive inadequate amounts of glucose, the body releases more glucose into the blood in an attempt to overcome the block to glucose entering the cells. The additional glucose cannot penetrate the cells, of course, and the glucose levels in the blood rise. High levels of blood and urine glucose is what causes the symptoms and signs of diabetes. For more, please re...

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OVERDOSE

Limited data are available with regard to overdosage in humans. In clinical trials in volunteers, AVANDIA has been administered at single oral doses of up to 20 mg and was well-tolerated. In the event of an overdose, appropriate supportive treatment should be initiated as dictated by the patient's clinical status.

CONTRAINDICATIONS

Initiation of AVANDIA in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated [see BOXED WARNING].

Last reviewed on RxList: 11/30/2011
This monograph has been modified to include the generic and brand name in many instances.