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Avapro

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Avapro

Overdosage
Contraindications

OVERDOSE

No data are available in regard to overdosage in humans. However, daily doses of 900 mg for 8 weeks were well-tolerated. The most likely manifestations of overdosage are expected to be hypotension and tachycardia; bradycardia might also occur from overdose. Irbesartan is not removed by hemodialysis.

To obtain up-to-date information about the treatment of overdosage, a good resource is a certified regional Poison Control Center. Telephone numbers of certified Poison Control Centers are listed in the Physicians' Desk Reference (PDR). In managing overdose, consider the possibilities of multiple-drug interactions, drug-drug interactions, and unusual drug kinetics in the patient.

Laboratory determinations of serum levels of irbesartan are not widely available, and such determinations have, in any event, no known established role in the management of irbesartan overdose.

Acute oral toxicity studies with irbesartan in mice and rats indicated acute lethal doses were in excess of 2000 mg/kg, about 25-and 50-fold the MRHD (300 mg) on a mg/m² basis, respectively.

CONTRAINDICATIONS

AVAPRO is contraindicated in patients who are hypersensitive to any component of this product.

Do not coadminister aliskiren with AVAPRO in patients with diabetes (see PRECAUTIONS: DRUG INTERACTIONS).

Last reviewed on RxList: 7/15/2014
This monograph has been modified to include the generic and brand name in many instances.

Overdosage
Contraindications
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