"Feb. 1, 2011 -- Patients treated with Avastin, a top-selling cancer medication, appear to have a 50% increased risk of dying from treatment-related adverse events compared to the use of chemotherapy alone, a new research review finds.
- To undergo routine blood pressure monitoring and to contact their health care provider if blood pressure is elevated.
- To immediately contact their health care provider for unusual bleeding, high fever, rigors, sudden onset of worsening neurological function, or persistent or severe abdominal pain, severe constipation, or vomiting.
- Of increased risk of wound healing complications during and following Avastin.
- Of increased risk of an arterial thromboembolic event.
- Of the increased risk for ovarian failure following Avastin treatment.
- Advise female patients that Avastin may cause fetal harm and to inform their healthcare provider with a known or suspected pregnancy. [See WARNINGS AND PRECAUTIONS, Use In Specific Populations]
- Advise females of reproductive potential to use effective contraception during treatment with Avastin and for 6 months after the last dose of Avastin. [See Use in Specific Populations]
- Advise nursing women that breastfeeding is not recommended during treatment with Avastin. [See Use in Specific Populations]
Last reviewed on RxList: 5/27/2015
This monograph has been modified to include the generic and brand name in many instances.
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