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Brand Names: Avastin

Generic Name: bevacizumab (Pronunciation: bev a CIZ oo mab)

• What is bevacizumab (Avastin)?
• What are the possible side effects of bevacizumab (Avastin)?
• What is the most important information I should know about bevacizumab (Avastin)?
• What should I discuss with my healthcare provider before using bevacizumab (Avastin)?
• How is bevacizumab used (Avastin)?
• What happens if I miss a dose (Avastin)?
• What happens if I overdose (Avastin)?
• What should I avoid while using bevacizumab (Avastin)?
• What other drugs will affect bevacizumab (Avastin)?
• Where can I get more information?

What is bevacizumab (Avastin)?

Bevacizumab is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Bevacizumab is used to treat a certain type of brain tumor as well as cancers of the kidney, colon, rectum, lung, or breast. It is usually given as part of a combination of cancer medicines.

Bevacizumab may also be used for other purposes not listed in this medication guide.

What are the possible side effects of bevacizumab (Avastin)?

Bevacizumab can cause a rare but serious neurologic disorder affecting the brain. Symptoms include headache, confusion, vision problems, feeling light-headed, fainting, and seizure (blackout or convulsions). These rare symptoms may occur within hours of your first dose of bevacizumab, or they may not appear for up to a year after your treatment started. Call your doctor at once if you have any of these side effects.

Some people receiving a bevacizumab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chills, wheezing, or chest pain during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• stomach pain with vomiting or constipation;
• black, bloody, or tarry stools;
• vomit that looks like blood or coffee grounds;
• sudden numbness or weakness, especially on one side of the body;
• sudden headache, confusion, problems with vision, speech, or balance;
• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
• feeling short of breath, even with mild exertion;
• swelling or rapid weight gain;
• feeling like you might pass out;
• urinating less than usual or not at all;
• fever, chills, body aches, flu symptoms;
• unusual bleeding such as nosebleeds, bleeding gums, or any bleeding that will not stop; or
• white patches or sores inside your mouth or on your lips.

Less serious side effects may include::

• diarrhea, stomach pain, loss of appetite;
• dry mouth, increased thirst;
• dizziness; or
• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bevacizumab (Avastin)?

Avoid having surgery while you are being treated with bevacizumab. You may have problems with wound healing, which could result in bleeding or infection.

If you need to have any type of surgery, you will need to stop receiving bevacizumab for at least 4 weeks while your surgical incision heals.

Before being treated with bevacizumab, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, a history of stroke or blood clots, or an open wound.

Some people receiving a bevacizumab injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chills, wheezing, or chest pain during the injection.

Call your doctor at once if you have serious side effects such as blood in your stools or vomit, sudden numbness or weakness (especially on one side of the body), sudden headache or confusion, problems with vision or speech, chest pain spreading to the arm or shoulder, shortness of breath, swelling, rapid weight gain, or flu symptoms.

Bevacizumab can cause a rare but serious neurologic disorder affecting the brain. Symptoms include headache, confusion, vision problems, feeling light-headed, fainting, and seizure (blackout or convulsions). These rare symptoms may occur within hours of your first dose of bevacizumab, or they may not appear for up to a year after your treatment started. Call your doctor at once if you have any of these side effects.

To be sure this medication is not causing harmful effects, your blood pressure will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled visits to your doctor.

This medication can affect a woman's fertility (ability to have children). Talk to your doctor about your specific risks.