Avelox (Moxifloxacin HCL) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 3, 2012

Avelox

Streptococcal Infections »

Group A streptococcal infections facts

Group A streptococci (GAS) are gram-positive coccal-shaped bacteria that produce beta-hemolysis (lysis of red blood cells producing clear or transparent areas) and appear as usually as a chain of two or more bacteria.
Group A Streptococcus (GAS) organisms are usually spread by direct human-to-human transfer. Occasionally, they can be spread by droplets or by a person touching items recently handled by an infected individual.
GAS can cause a wide range of diseases, but most notably, strep throat; other diseases (or complications) include scarlet fever, rheumatic fever, kidney damage, skin and wound infections and occasionally, necrotizing fasciitis and toxic shock syndrome.
Symptoms and signs of GAS disease are variable and are related to the body area that is undergoing the infection; for example, sore throat, throat erythema, and swollen lymph nodes in strep thro...

Read the Streptococcal Infections article »

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AVELOX
(moxifloxacin hydrochloride)

WARNING

Fluoroquinolones, including AVELOX®, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants [see WARNINGS AND PRECAUTIONS].

Fluoroquinolones, including AVELOX, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid AVELOX in patients with known history of myasthenia gravis [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION

AVELOX (moxifloxacin hydrochloride) is a synthetic broad spectrum antibacterial agent for oral and intravenous administration. Moxifloxacin, a fluoroquinolone, is available as the monohydrochloride salt of 1-cyclopropyl-7-[(S,S)2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3 quinoline carboxylic acid. It is a slightly yellow to yellow crystalline substance with a molecular weight of 437.9. Its empirical formula is C₂₁H₂₄FN₃O₄*HCl and its chemical structure is as follows:

AVELOX (moxifloxacin hydrochloride) Structural Formula Illustration

AVELOX Tablets

AVELOX Tablets are available as film-coated tablets containing moxifloxacin hydrochloride (equivalent to 400 mg moxifloxacin).
The inactive ingredients are microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol and ferric oxide.

AVELOX IV

AVELOX IV is available in ready-to-use 250 mL latex-free flexibags as a sterile, preservative free, 0.8% sodium chloride aqueous solution of moxifloxacin hydrochloride (containing 400 mg moxifloxacin) with pH ranging from 4.1 to 4.6.
The appearance of the intravenous solution is yellow. The color does not affect, nor is it indicative of, product stability.
The inactive ingredients are sodium chloride, USP, Water for Injection, USP, and may include hydrochloric acid and/or sodium hydroxide for pH adjustment.
AVELOX IV contains approximately 34.2 mEq (787 mg) of sodium in 250 mL.

What are the possible side effects of moxifloxacin (Avelox)?

Stop using moxifloxacin and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using moxifloxacin and call your doctor at once if you have any of these serious side effects:

dizziness, fainting, fast or pounding heartbeat;
sudden pain or swelling near your joints (especially in your arm or ankle);
diarrhea that is watery or bloody;
confusion, hallucinations, depression, unusual...

Read All Potential Side Effects and See Pictures of Avelox »

What are the precautions when taking moxifloxacin hcl (Avelox)?

Before taking moxifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, heart problems (e.g., recent heart attack), joint/tendon problems (e.g., tendonitis, bursitis), liver disease, myasthenia gravis, nervous system disorder (e.g., peripheral neuropathy), seizure disorder, conditions that increase your risk of seizures (e.g., brain/head injury, brain tumors, cerebral atherosclerosis).

Moxifloxacin may cause...

Read All Potential Precautions of Avelox »

Last reviewed on RxList: 10/26/2011
This monograph has been modified to include the generic and brand name in many instances.