Avelox (Moxifloxacin HCL) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Avelox

Pneumonia »

Pneumonia facts

Pneumonia is a lung infection that can be caused by different types of microorganisms, including bacteria, viruses, and fungi.
Symptoms of pneumonia include cough with sputum production, fever, and sharp chest pain on inspiration (breathing in).
Pneumonia is suspected when a doctor hears abnormal sounds in the chest, and the diagnosis is confirmed by a chest X-ray.
Bacteria causing pneumonia can be identified by sputum culture.
A pleural effusion is a fluid collection around the inflamed lung.
Bacterial and fungal (but not viral) pneumonia can be treated with antibiotics.

What is pneumonia?

Pneumonia is an infection of one or both lungs which is usually caused by bacteria, viruses, or fungi. Prior to the discovery of antibiotics, one-third of all people who developed pneumonia subsequently died fro...

Read the Pneumonia article »

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AVELOX
(moxifloxacin hydrochloride)

WARNING

Fluoroquinolones, including AVELOX®, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants [see WARNINGS AND PRECAUTIONS].

Fluoroquinolones, including AVELOX, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid AVELOX in patients with known history of myasthenia gravis [see WARNINGS AND PRECAUTIONS].

DRUG DESCRIPTION

AVELOX (moxifloxacin hydrochloride) is a synthetic broad spectrum antibacterial agent for oral and intravenous administration. Moxifloxacin, a fluoroquinolone, is available as the monohydrochloride salt of 1-cyclopropyl-7-[(S,S)2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3 quinoline carboxylic acid. It is a slightly yellow to yellow crystalline substance with a molecular weight of 437.9. Its empirical formula is C₂₁H₂₄FN₃O₄*HCl and its chemical structure is as follows:

AVELOX (moxifloxacin hydrochloride) Structural Formula Illustration

AVELOX Tablets

AVELOX Tablets are available as film-coated tablets containing moxifloxacin hydrochloride (equivalent to 400 mg moxifloxacin).
The inactive ingredients are microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol and ferric oxide.

AVELOX IV

AVELOX IV is available in ready-to-use 250 mL latex-free flexibags as a sterile, preservative free, 0.8% sodium chloride aqueous solution of moxifloxacin hydrochloride (containing 400 mg moxifloxacin) with pH ranging from 4.1 to 4.6.
The appearance of the intravenous solution is yellow. The color does not affect, nor is it indicative of, product stability.
The inactive ingredients are sodium chloride, USP, Water for Injection, USP, and may include hydrochloric acid and/or sodium hydroxide for pH adjustment.
AVELOX IV contains approximately 34.2 mEq (787 mg) of sodium in 250 mL.

What are the possible side effects of moxifloxacin (Avelox)?

Stop using moxifloxacin and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using moxifloxacin and call your doctor at once if you have any of these serious side effects:

dizziness, fainting, fast or pounding heartbeat;
sudden pain or swelling near your joints (especially in your arm or ankle);
diarrhea that is watery or bloody;
confusion, hallucinations, depression, unusual...

Read All Potential Side Effects and See Pictures of Avelox »

What are the precautions when taking moxifloxacin hcl (Avelox)?

Before taking moxifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, levofloxacin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, heart problems (e.g., recent heart attack), joint/tendon problems (e.g., tendonitis, bursitis), liver disease, myasthenia gravis, nervous system disorder (e.g., peripheral neuropathy), seizure disorder, conditions that increase your risk of seizures (e.g., brain/head injury, brain tumors, cerebral atherosclerosis).

Moxifloxacin may cause...

Read All Potential Precautions of Avelox »

Last reviewed on RxList: 10/26/2011
This monograph has been modified to include the generic and brand name in many instances.