" Migraine medications overview
Migraine is a serious, potentially life-threatening neurological disease that affects nearly 36 million Americans, the majority of whom are women. The American Migraine Foundation estimates that one in ev"...
Signs And Symptoms
Patients and volunteers receiving single oral doses of 100 to 150 mg of almotriptan did not experience significant adverse events. Six additional normal volunteers received single oral doses of 200 mg without serious adverse events. During clinical trials with AXERT® (almotriptan malate), one patient ingested 62.5 mg in a 5-hour period and another patient ingested 100 mg in a 38-hour period. Neither patient experienced adverse reactions.
There is no specific antidote to AXERT® . In cases of severe intoxication, intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system.
Clinical and electrocardiographic monitoring should be continued for at least 20 hours even if clinical symptoms are not observed.
Ischemic Or Vasospastic Coronary Artery Disease, Or Other Significant Underlying Cardiovascular Disease
Do not use AXERT® (almotriptan malate) in patients with ischemic heart disease (angina pectoris, history of myocardial infarction, or documented silent ischemia), or in patients who have symptoms or findings consistent with ischemic heart disease, coronary artery vasospasm, including Prinzmetal's variant angina, or other significant underlying cardiovascular disease [see WARNINGS AND PRECAUTIONS].
Peripheral Vascular Disease
Because AXERT® may increase blood pressure, do not use AXERT® in patients with uncontrolled hypertension [see WARNINGS AND PRECAUTIONS].
Ergotamine-Containing And Ergot-Type Medications
Concomitant Use With 5-HT1 Agonists (e.g., Triptans)
AXERT® and other 5-HT1 agonists (e.g., triptans) should not be administered within 24 hours of each other [see WARNINGS AND PRECAUTIONS].
Hemiplegic Or Basilar Migraine
AXERT® is contraindicated in patients with known hypersensitivity to almotriptan or any of its inactive ingredients.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 8/21/2014
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