Axid (Nizatidine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Axid

Hiatal Hernia »

What is a hiatal hernia?

A hiatal hernia is an anatomical abnormality in which part of the stomach protrudes through the diaphragm and up into the chest. Although hiatal hernias are present in approximately 15% of the population, they are associated with symptoms in only a minority of those afflicted.

Normally, the esophagus or food tube passes down through the chest, crosses the diaphragm, and enters the abdomen through a hole in the diaphragm called the esophageal hiatus. Just below the diaphragm, the esophagus joins the stomach. In individuals with hiatal hernias, the opening of the esophageal hiatus (hiatal opening) is larger than normal, and a portion of the upper stomach slips up or passes (herniates) through the hiatus and into the chest. Although hiatal hernias are occasionally seen in infants where they probably have been present from birth, most hiatal hernias in adults are believed to have developed over many years....

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AXID®
(nizatidine) Capsules, USP

DRUG DESCRIPTION

Axid® (Nizatidine, USP) is a histamine H₂-receptor antagonist. Chemically, it is N-[2-[[[2-[(dimethylamino)methyl]-4-thia-zolyl]methyl]thio]ethyl]-Nⁱ-methyl-2-nitro-1,1-ethenediamine.

The structural formula is as follows:

Nizatidine

Nizatidine has the empirical formula C₁₂H₂₁N₅O₂S₂ representing a molecular weight of 331.47. It is an off-white to buff crystalline solid that is soluble in water. Nizatidine has a bitter taste and mild sulfur-like odor. Each Pulvule^®(capsule) contains for oral administration gelatin, pregelatinized starch, dimethicone, starch, titanium dioxide, yellow iron oxide, 150 mg (0.45 mmol) or 300 mg (0.91 mmol) of nizatidine, and other inactive ingredients. The 150-mg Pulvule also contains magnesium stearate, and the 300-mg Pulvule also contains croscarmellose sodium, povidone, red iron oxide, and talc.

What are the possible side effects of nizatidine (Axid, Axid AR, Axid Pulvules)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using nizatidine and call your doctor at once if you have a serious side effect such as:

pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
unusual bleeding, purple or red pinpoint spots under your skin;
skin rash, bruising, severe tingling, numbness, pain, muscle...

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What are the precautions when taking nizatidine (Axid)?

Before taking nizatidine, tell your doctor or pharmacist if you are allergic to it; or to other H2 blockers (e.g., cimetidine, famotidine, ranitidine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: immune system problems, kidney problems, liver problems, certain lung diseases (chronic obstructive pulmonary disease-COPD), diabetes, other stomach problems (e.g., tumors).

Some symptoms may actually be signs of a more serious condition. Tell your doctor immediately if you have: heartburn with lightheadedness/sweating/dizziness, chest/shoulder/jaw...

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Last reviewed on RxList: 2/14/2006
This monograph has been modified to include the generic and brand name in many instances.