Recommended Topic Related To:

Axid

"Overview of Heartburn

The esophagus is a tube that connects the mouth to the stomach. It is made of muscles that work to push food toward the stomach in rhythmic waves. Once in the stomach, food is prevented from refluxing (moving b"...

Axid

Axid

INDICATIONS

Axid (nizatidine) is indicated for up to 8 weeks for the treatment of active duodenal ulcer. In most patients, the ulcer will heal within 4 weeks.

Axid (nizatidine) is indicated for maintenance therapy for duodenal ulcer patients, at a reduced dosage of 150 mg h.s. after healing of an active duodenal ulcer. The consequences of continuous therapy with Axid (nizatidine) for longer than 1 year are not known.

Axid (nizatidine) is indicated for up to 12 weeks for the treatment of endoscopically diagnosed esophagitis, including erosive and ulcerative esophagitis, and associated heartburn due to GERD.

Axid (nizatidine) is indicated for up to 8 weeks for the treatment of active benign gastric ulcer. Before initiating therapy, care should be taken to exclude the possibility of malignant gastric ulceration.

DOSAGE AND ADMINISTRATION

Active Duodenal Ulcer — The recommended oral dosage for adults is 300 mg once daily at bedtime. An alternative dosage regimen is 150 mg twice daily.

Maintenance of Healed Duodenal Ulcer — The recommended oral dosage for adults is 150 mg once daily at bedtime.

Gastroesophageal Reflux Disease — The recommended oral dosage in adults for the treatment of erosions, ulcerations, and associated heartburn is 150mg twice daily.

Active Benign Gastric Ulcer — The recommended oral dosage is 300 mg given either as 150 mg twice daily or 300 mg once daily at bedtime. Prior to treatment, care should be taken to exclude the possibility of malignant gastric ulceration.

Dosage Adjustment for Patients With Moderate to Severe Renal Insufficiency — The dose for patients with renal dysfunction should be reduced as follows:

Active Duodenal Ulcer, GERD and Benign Gastric Ulcer

Ccr
Dose
20-50 mL/min
150 mg daily
<20 mL/min
150 mg every other day
Maintenance Therapy
Ccr
Dose
20-50 mL/min
150 mg every other day
<20 mL/min
150 mg every 3 days

Some elderly patients may have creatinine clearances of less than 50 mL/min, and, based on pharmacokinetic data in patients with renal impairment, the dose for such patients should be reduced accordingly. The clinical effects of this dosage reduction in patients with renal failure have not been evaluated.

HOW SUPPLIED

Axid (nizatidine) ® Pulvules®* are available in:

The 150-mg Pulvules are imprinted with "150" on the opaque dark yellow cap and "AXID (nizatidine) " and "Reliant" on the opaque pale yellow body, using black ink. They are available as follows:

Bottles of 60 NDC 65726-144-15

 

The 300-mg Pulvules are imprinted with "300" on the opaque brown cap and "AXID (nizatidine) " and "Reliant" on the opaque pale yellow body, using black ink. They are available as follows:

Bottles of 30 NDC 65726-145-10

*Pulvules® (filled gelatin capsules, Lilly)

Store at controlled room temperature 20° to 25°C (68° to 77°F) in a tightly closed container [see USP].

The USP defines controlled room temperature as: A temperature maintained thermostatically that encompasses the usual and customary working environment of 20° to 25°C (68° to 77°F); that results in a mean kinetic temperature calculated to be not more than 25°C; and that allows for excursions between 15° and 30°C (59° and 86°F) that are experienced in pharmacies, hospitals, and warehouses.

March 2005
Distributed by: Reliant Pharmaceuticals, Inc. Liberty Corner, NJ 07938, USA
Address Medical Inquiries to: Reliant Pharmaceuticals, Inc.
Medical Affairs 110 Allen Road
Liberty Corner, NJ 07938, USA © 2005 Reliant Pharmaceuticals, Inc., 214R400, PRINTED IN U.S.A.
FDA revision date:12/23/05

Last reviewed on RxList: 2/14/2006
This monograph has been modified to include the generic and brand name in many instances.

A A A

Axid - User Reviews

Axid User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Axid sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


GI Disorders

Get the latest treatment options.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations