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The following adverse reactions have been observed in women taking progestins:
- Breakthrough bleeding
- Change in menstrual flow
- Changes in weight (decreases, increases)
- Changes in the cervical squamo-columnar junction and cervical secretions
- Cholestatic jaundice
- Rash (allergic) with and without pruritus
- Melasma or chloasma
- Clinical depression
- Breast enlargement/tenderness
- Abnormalities of liver tests (i.e., AST, ALT, Bilirubin)
- Decreased HDL cholesterol and increased LDL/HDL ratio
- Mood swings
- Anaphylactic/anaphylactoid reactions
- Thrombotic and thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism, retinal vascular thrombosis, cerebral thrombosis and embolism)
- Optic neuritis (which may lead to partial or complete loss of vision)
Read the Aygestin (norethindrone) Side Effects Center for a complete guide to possible side effects
Drug/Laboratory Tests Interactions
- Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of antifactor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity.
- Increased thyroid-binding globulin (TBG) levels leading to increased circulating total thyroid hormone levels as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.
- Other binding proteins may be elevated in serum (i.e., corticosteroid binding globulin (CBG), sex hormone binding globulin (SHBG)) leading to increased circulating corticosteroid and sex steroids, respectively. Free or biologically active hormone concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).
- Increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglycerides levels.
- Impaired glucose metabolism.
- Reduced response to metyrapone test.
Read the Aygestin Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 4/19/2016
Additional Aygestin Information
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