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home > drugs a-z list > aygestin (norethindrone) drug center > aygestin (norethindrone) drug - side effects and drug interactions
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Aygestin
What is endometriosis?
Endometriosis is the abnormal growth of cells (endometrial cells) similar to those that form the inside of the uterus, but in a location outside of the uterus. Endometrial cells are cells that are shed each month during menstruation. The cells of endometriosis attach themselves to tissue outside the uterus and are called endometriosis implants. These implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They can also be found in the vagina, cervix, and bladder, although less commonly than other locations in the pelvis. Rarely, endometriosis implants can occur outside the pelvis, on the liver, in old surgery scars, and even in or around the lung or brain. Endometrial implants, while they can cause problems, are benign (not cancerous).
Who is affected by endometriosis?
Endometriosis affects w...
Aygestin
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SIDE EFFECTS
See “WARNINGS” for further information on Retinal vascular thrombosis, Thrombotic and thromboembolism events, and Use in pregnancy. The following adverse reactions have been observed in women taking progestins:
Breakthrough bleeding.
Spotting.
Change in menstrual flow.
Amenorrhea.
Edema.
Changes in weight (decreases, increases).
Changes in cervical erosion and cervical secretions.
Cholestatic jaundice.
Rash (allergic) with and without pruritus.
Melasma or chloasma.
Mental depression.
Acne.
Breast enlargement/tenderness.
Headache/migraine.
Urticaria.
Abnormalities of liver tests (i.e., AST, ALT, Bilirubin).
Mood swings.
Nausea.
Insomnia.
Anaphylactic/anaphylactoid reactions.
Thrombotic and thromboembolic events (e.g., deep vein thrombosis, pulmonary
embolism, retinal vascular thrombosis, cerebral thrombosis and embolism).
Optic neuritis (which may lead to partial or complete loss of vision).
Progestins may alter the result of pregnanediol determinations. The following
laboratory results may be altered by the concomitant use of estrogens with progestins:
Hepatic function.
Coagulation tests - increase in prothrombin, factors VII, VIII, IX, and X.
Increase in PBI, BEI, and a decrease in T3 uptake.
Reduced response to metyrapone test.
The following adverse reactions have been observed in patients receiving estrogen-progestogen combination drugs:
- Rise in blood pressure in susceptible individuals.
- Premenstrual-like syndrome.
- Changes in libido.
- Changes in appetite.
- Cystitis-like syndrome.
- Headache.
- Nervousness.
- Dizziness.
- Fatigue.
- Backache.
- Hirsutism.
- Loss of scalp hair.
- Erythema multiforme.
- Erythema nodosum.
- Hemorrhagic eruption.
- Itching.
In view of these observations, patients on progestogen therapy should be carefully observed.
DRUG INTERACTIONS
No information provided.
Last reviewed on RxList: 3/31/2009
This monograph has been modified to include the generic and brand name in many instances.
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