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Aygestin Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Aygestin (norethindrone) is used for birth control (contraception) to prevent pregnancy. It is also used to treat menstrual disorders, endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance. Aygestin is a form of progesterone, a female hormone. This medication is available in generic form. Common side effects include nausea, vomiting, headache, dizziness, mood swings, trouble sleeping, weight gain/loss, acne, breast swelling/tenderness, change in sexual interest, unwanted hair growth, or hair loss.
The dosage and the duration of treatment with Aygestin is based on the patient's medical condition and response to therapy. Follow doctor's instructions. Withdrawal bleeding usually occurs within three to seven days after discontinuing Aygestin therapy. Aygestin may interact with griseofulvin, rifampin, St. John's wort, ketoconazole or itraconazole, barbiturates, or HIV medicines. Tell your doctor all medications you are taking. Smoking combined with this medication increases your risk for strokes, blood clots, high blood pressure, and heart attacks. Aygestin must not be used during pregnancy because it may harm a fetus, especially during the first 4 months of pregnancy. This drug passes into breast milk. Consult your doctor before breast-feeding.
Our Aygestin (norethindrone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Aygestin in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have any of these serious side effects:
- sudden numbness or weakness, especially on one side of the body;
- sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance;
- pain or swelling in one or both legs;
- migraine headache;
- swelling in your hands or feet, rapid weight gain;
- symptoms of depression (sleep problems, weakness, mood changes);
- severe pelvic pain;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
- nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
- mild nausea, vomiting, bloating, stomach cramps;
- breast pain, swelling, or tenderness;
- freckles or darkening of facial skin;
- increased acne or hair growth;
- changes in weight;
- vaginal itching or discharge;
- skin itching or rash;
- changes in your menstrual periods, decreased sex drive; or
- mild headache.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Aygestin (Norethindrone)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Aygestin Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these serious side effects occur: changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, changes in menstrual flow, no menstrual bleeding), change in vaginal discharge, depression, swelling of the hands/feet, frequent/burning/painful urination, yellowing eyes/skin, dark patches on the skin or face (melasma).
This medication may rarely cause very serious (possibly fatal) problems from blood clots (e.g., heart attack, stroke, blood clots in the lungs or legs, blindness). Seek immediate medical attention if you experience any of the following: chest/jaw/left arm pain, weakness on one side of the body, slurred speech, sudden vision changes (e.g., blurred/double vision, loss of vision, bulging eyes), confusion, sudden severe headache, severe dizziness, fainting, trouble breathing, coughing up blood, pain/redness/swelling/weakness of the arms/legs, calf pain/swelling that is warm to the touch.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Aygestin (Norethindrone)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Aygestin FDA Prescribing Information: Side Effects
See "WARNINGS" for further information on Retinal vascular thrombosis, Thrombotic and thromboembolism events, and Use in pregnancy. The following adverse reactions have been observed in women taking progestins:
Change in menstrual flow.
Changes in weight (decreases, increases).
Changes in cervical erosion and cervical secretions.
Rash (allergic) with and without pruritus.
Melasma or chloasma.
Abnormalities of liver tests (i.e., AST, ALT, Bilirubin).
Thrombotic and thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism, retinal vascular thrombosis, cerebral thrombosis and embolism).
Optic neuritis (which may lead to partial or complete loss of vision).
Progestins may alter the result of pregnanediol determinations. The following laboratory results may be altered by the concomitant use of estrogens with progestins:
Coagulation tests - increase in prothrombin, factors VII, VIII, IX, and X.
Increase in PBI, BEI, and a decrease in T3 uptake.
Reduced response to metyrapone test.
The following adverse reactions have been observed in patients receiving estrogen-progestogen combination drugs:
- Rise in blood pressure in susceptible individuals.
- Premenstrual-like syndrome.
- Changes in libido.
- Changes in appetite.
- Cystitis-like syndrome.
- Loss of scalp hair.
- Erythema multiforme.
- Erythema nodosum.
- Hemorrhagic eruption.
In view of these observations, patients on progestogen therapy should be carefully observed.
Read the entire FDA prescribing information for Aygestin (Norethindrone)
Additional Aygestin Information
Aygestin - User Reviews
Aygestin User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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