Azasite (Azithromycin Ophthalmic Solution) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 25, 2012

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Azasite

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AZASITE®
(azithromycin ophthalmic solution) 1% Sterile Topical Ophthalmic Drops

DRUG DESCRIPTION

AzaSite (azithromycin ophthalmic solution) is a 1% sterile aqueous topical ophthalmic solution of azithromycin formulated in DuraSite® (polycarbophil, edetate disodium, sodium chloride). AzaSite (azithromycin ophthalmic solution) is an off-white, viscous liquid with an osmolality of approximately 290 mOsm/kg.

Preservative: 0.003% benzalkonium chloride. Inactives: mannitol, citric acid, sodium citrate, poloxamer 407, polycarbophil, edetate disodium (EDTA), sodium chloride, water for injection, and sodium hydroxide to adjust pH to 6.3.

Azithromycin is a macrolide antibiotic with a 15-membered ring. Its chemical name is(2R,3S,4R,5R,8R,10R,HR,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-l-oxa-6-aza-cyclopentadecan-15-one, and the structural formula is:

AZASITE® (azithromycin ophthalmic solution)
(azithromycin) Structural Formula Illustration

Azithromycin has a molecular weight of 749, and its empirical formula is C₃₈H₇₂N₂O₁₂.

What are the possible side effects of azithromycin ophthalmic (AzaSite)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

drainage or crusting of your eye;
severe irritation after using the eye drops;
feeling like there is something in your eye;
watery eyes, increased light sensitivity;
eye redness or swelling; or
any signs of a new...

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What are the precautions when taking azithromycin ophthalmic solution (Azasite)?

Before using azithromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics such as erythromycin or clarithromycin; or to ketolide antibiotics such as telithromycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when...

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Last reviewed on RxList: 5/24/2011
This monograph has been modified to include the generic and brand name in many instances.