Azilect (Rasagiline) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 16, 2012

Azilect

Parkinson's Disease Clinical Trials »

Introduction to Clinical Trials for Parkinson's Disease

You may have heard about clinical trials from your doctor, read or heard advertisements in the newspaper or on the radio, or found out about trials in your area through a support group or association. Before you decide to participate in a trial, you should be aware of the potential benefits and risks. This guide provides a brief overview of the clinical trial process.

What Is a Clinical Trial?

A clinical trial is a research program conducted in patients to evaluate a new medical treatment, drug, or device. The purpose of clinical trials is to find new and improved methods of treating diseases and special conditions.

During a clinical trial, doctors use the best available treatment as a standard to evaluate new treatments. The new treatments are hoped to be at least as effective as -- or possibly more effective than -- the standard.

New treatment options are ...

Read the Parkinson's Disease Clinical Trials article »

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AZILECT®
(rasagiline mesylate) Tablets for Oral Use

DRUG DESCRIPTION

AZILECT® tablets contain rasagiline (as the mesylate), a propargylamine-based d rug indicated for the treatment of idiopathic Parkinson's disease. It is designated chemically as: 1H-Inden-1-amine, 2, 3dihydro-N-2-propynyl-, (1R)-, methanesulfonate. The empirical formula of rasagiline mesylate is (C₁₂H₁₃N)CH₄SO₃ and its molecular weight is 267.34. Its structural formula is:

AZILECT® (rasagiline mesylate) Structural Formula Illustration

Rasagiline mesylate is a white to off-white powder, freely soluble in water or ethanol and sparingly soluble in isopropanol. Each AZILECT tablet for oral administration contains rasagiline mesylate equivalent to 0.5 mg or 1 mg of rasagiline base.

Each AZILECT (rasagiline) tablet also contains the following inactive ingredients: mannitol, starch, pregelatinized starch, colloidal silicon dioxide, stearic acid and talc.

What are the possible side effects of rasagiline (Azilect)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using rasagiline and call your doctor at once if you have any of these serious side effects:

increased blood pressure (sudden and severe headache, confusion, blurred vision, chest pain, nausea, vomiting, seizure);
sudden numbness or weakness (especially on one side of the body), problems with speech or balance;
unusual thoughts or behavior,...

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What are the precautions when taking rasagiline (Azilect)?

Before taking rasagiline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: cerebrovascular disease (e.g., stroke), heart disease (e.g., coronary artery disease, heart attack, history of chest pain, congestive heart failure), personal/family history of high blood pressure, history of severe/frequent headaches, liver disease, sore in the stomach/intestine/esophagus (peptic ulcer), bleeding problems, diabetes, personal/family history of mental/mood disorders (e.g., schizophrenia, bipolar disorder),...

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Last reviewed on RxList: 12/29/2009
This monograph has been modified to include the generic and brand name in many instances.