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Baclofen

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Baclofen

CLINICAL PHARMACOLOGY

ACTIONS

The precise mechanism of action of baclofen is not fully known. Baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Last reviewed on RxList: 11/20/2007
This monograph has been modified to include the generic and brand name in many instances.

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