Recommended Topic Related To:

Baclofen

"Nov. 18, 2012 -- Researchers say they've been able to use nanoparticles to stop multiple sclerosis (MS) in mice that are bred to have the disease.

The particles are about 200 times smaller than the thickness of a human hair. They are "...

Baclofen

Baclofen

CLINICAL PHARMACOLOGY

ACTIONS

The precise mechanism of action of baclofen is not fully known. Baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. Although baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is an analog of the putative inhibitory neurotransmitter gamma-aminobutyric acid (GABA), there is no conclusive evidence that actions on GABA systems are involved in the production of its clinical effects. In studies with animals, baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is rapidly and extensively absorbed and eliminated. Absorption may be dose-dependent, being reduced with increasing doses. Baclofen (baclofen (baclofen (baclofen tablets) tablets) tablets) is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.

Last reviewed on RxList: 11/20/2007
This monograph has been modified to include the generic and brand name in many instances.

A A A

Baclofen - User Reviews

Baclofen User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Baclofen sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Multiple Sclerosis

Get the latest treatment options.

advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations