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Bal in Oil Ampules

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Bal in Oil Ampules

CLINICAL PHARMACOLOGY

The sulfhydryl groups of dimercaprol form complexes with certain heavy metals thus preventing or reversing the metallic binding of sulfhydryl-containing enzymes. The complex is excreted. The sustained presence of dimercaprol promotes continued excretion of the metallic poisons - arsenic, gold and mercury. It is also used in combination with Edetate Calcium Disodium Injection USP to promote the excretion of lead.

Animal Toxicology

The intramuscular LD50 in rats is approximately 105 mg/kg; intraperitoneally 140 mg/kg. The intraperitoneal LD80 in mice is approximately 125 mg/kg.

JR. PHARM. EXPER. THER. 87, Supplement Aug. 1946.

Last reviewed on RxList: 5/22/2007
This monograph has been modified to include the generic and brand name in many instances.

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