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The sulfhydryl groups of dimercaprol form complexes with certain heavy metals thus preventing or reversing the metallic binding of sulfhydryl-containing enzymes. The complex is excreted. The sustained presence of dimercaprol promotes continued excretion of the metallic poisons - arsenic, gold and mercury. It is also used in combination with Edetate Calcium Disodium Injection USP to promote the excretion of lead.

Animal Toxicology

The intramuscular LD₅₀ in rats is approximately 105 mg/kg; intraperitoneally 140 mg/kg. The intraperitoneal LD₈₀ in mice is approximately 125 mg/kg.

JR. PHARM. EXPER. THER. 87, Supplement Aug. 1946.

Last reviewed on RxList: 5/22/2007
This monograph has been modified to include the generic and brand name in many instances.