Local pain and tenderness at the injection site, urticaria and angioedema may occur; anaphylactic reactions, although rare, have been reported following the injection of human immune globulin preparations.19
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Although administration of Hepatitis B Immune Globulin (Human) did not interfere with measles vaccination,18 it is not known whether Hepatitis B Immune Globulin (Human) may interfere with other live virus vaccines. Therefore, use of such vaccines should be deferred until approximately 3 months after Hepatitis B Immune Globulin (Human) administration. Hepatitis B Vaccine may be administered at the same time, but at a different injection site, without interfering with the immune response.16 No interactions with other products are known.
18. Beasley RP, Hwang LY: Measles vaccination not interfered with by hepatitis B immune globulin. Lancet 1:161, 1982.
19. Ellis EF, Henney CS: Adverse reactions following administration of human gamma globulin. J Allerg 43(1):45-54, 1969.
Last reviewed on RxList: 10/29/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional BayHep B Information
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