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Brand Names: B & O Supprettes 15-A, B & O Supprettes 16-A

Generic Name: belladonna and opium (rectal) (Pronunciation: BEL a DON a and OH pee um)

• What is belladonna and opium (Belladonna and Opium)?
• What are the possible side effects of belladonna and opium (Belladonna and Opium)?
• What is the most important information I should know about belladonna and opium (Belladonna and Opium)?
• What should I discuss with my health care provider before using belladonna and opium rectal (Belladonna and Opium)?
• How should I use belladonna and opium rectal (Belladonna and Opium)?
• What happens if I miss a dose (Belladonna and Opium)?
• What happens if I overdose (Belladonna and Opium)?
• What should I avoid while using belladonna and opium (Belladonna and Opium)?
• What other drugs will affect belladonna and opium (Belladonna and Opium)?
• Where can I get more information?

What is belladonna and opium (Belladonna and Opium)?

Belladonna is a natural substance made from a toxic plant. The medicinal form of belladonna has many effects in the body, such as decreasing muscle activity.

Opium is also a natural substance made from the seeds of a plant. The medicinal form of opium is a narcotic pain reliever.

The combination of belladonna and opium is used to treat moderate to severe pain caused by muscle spasms in the tubes that connect the kidneys to the bladder.

Belladonna and opium may also be used for other purposes not listed in this medication guide.

What are the possible side effects of belladonna and opium (Belladonna and Opium)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• painful or difficult urination;
• urinating less than usual or not at all;
• fast heart rate;
• weak, shallow breathing;
• extreme weakness, feeling like you might pass out;
• headache, confusion; or
• severe constipation and stomach pain.

Less serious side effects may include:

• drowsiness, dizziness;
• blurred vision;
• nausea, vomiting, constipation;
• dry mouth, dry eyes;
• decreased sense of taste; or
• impotence, loss of interest in sex, or trouble having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about belladonna and opium (Belladonna and Opium)?

Do not take belladonna and opium rectal by mouth. It is for use only in your rectum.

Do not use belladonna and opium if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Do not use belladonna and opium if you are also using furazolidone (Furoxone), linezolid (Zyvox), moclobemide, pramlintide (Symlin), procarbazine (Matulane), naltrexone (ReVia), or potassium supplement tablets or capsules.

You should not use belladonna and opium if you have glaucoma, urination problems, a blockage in your stomach or intestines, a head injury, seizures, diarrhea caused by infection, severe liver or kidney disease, severe bleeding, myasthenia gravis, asthma, or if you are intoxicated or debilitated.

Before using this medication, tell your doctor if you have liver or kidney disease, heart disease, high or low blood pressure, a stomach or intestinal disorder, breathing problems, mental illness, spinal curvature, gallbladder disease, Addison's disease, underactive thyroid, drug or alcohol addiction, or if you are allergic to any narcotic medications.

Opium may be habit-forming and should be used only by the person it was prescribed for. Belladonna and opium rectal suppositories should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.