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Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. Stimulation is particularly likely in pediatric patients. Atropine-like signs and symptoms; dry mouth; fixed, dilated pupils; flushing; and gastrointestinal symptoms may also occur. Stimulants should not be used.
Vasopressors may be used to treat hypotension.
Use in Neonates or Premature Infants
This drug should not be used in neonates or premature infants.
Use in Nursing Mothers
Use as a Local Anesthetic
Because of the risk of local necrosis, this drug should not be used as a local anesthetic.
Antihistamines are also contraindicated in the following conditions: Hypersensitivity, to diphenhydramine hydrochloride and other antihistamines of similar chemical structure.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Benadryl Injection Information
- Benadryl Injection Drug Interactions Center: diphenhydramine hcl inj
- Benadryl Injection Side Effects Center
- Benadryl Injection Overview including Precautions
- Benadryl Injection FDA Approved Prescribing Information including Dosage
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