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Benadryl Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Benadryl (diphenhydramine) is an antihistamine used to treat allergies, hives, insomnia, motion sickness, and mild cases of Parkinsonism. Benadryl is available in generic form and over-the-counter (OTC). Common side effects of Benadryl include:
- disturbed coordination,
- dry mouth/nose/throat,
- difficulty urinating or an enlarged prostate,
- upset stomach,
- blurred vision,
- double vision,
- loss of appetite,
- headache, or
A typical dose of Benadryl is 25-50 mg every 4-6 hours. Benadryl may interact with monoamine oxidase inhibitors (MAOIs), other over-the-counter cough, cold, allergy, or insomnia medications, anxiety or sleep medicines, antidepressants, or any other medications that make you feel drowsy, sleepy, or relaxed. Tell your doctor all medications and supplements you use. Benadryl has not been adequately evaluated in pregnant women. Benadryl is secreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature infants, antihistamines should not be used by nursing mothers.
Our Benadryl Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Benadryl in Detail - Patient Information: Side Effects
Stop taking diphenhydramine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
Other, less serious side effects may be more likely to occur. Continue to take diphenhydramine and talk to your doctor if you experience
- sleepiness, fatigue, or dizziness;
- dry mouth; or
- difficulty urinating or an enlarged prostate.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Benadryl (Diphenhydramine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Benadryl Overview - Patient Information: Side Effects
To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as restlessness, confusion), difficulty urinating, fast/irregular heartbeat.
Get medical help right away if you have any very serious side effects, including: seizures.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Benadryl (Diphenhydramine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Benadryl FDA Prescribing Information: Side Effects
When using this product:
- marked drowsiness may occur
- avoid alcoholic drinks
- alcohol, sedatives, and tranquilizers may increase drowsiness
- excitability may occur, especially in children
- be careful when driving a motor vehicle or operating machinery
Read the entire FDA prescribing information for Benadryl (Diphenhydramine)
Additional Benadryl Information
Benadryl - User Reviews
Benadryl User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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