BenzaClin (Clindamycin and Benzoyl Peroxide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 8, 2012

BenzaClin

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What is acne?

Acne (acne vulgaris, common acne) is a disease of the hair follicles of the face, chest, and back that affects almost all males and females during puberty; the only exception being teenage members of a few primitive isolated tribes living in Neolithic societies. It is not caused by bacteria, although bacteria play a role in its development. It is not unusual for some women to develop acne in their mid- to late-20s.

Acne appears on the skin as...

congested pores ("comedones"), also known as blackheads or whiteheads,
tender red bumps also known as pimples or zits,
pustules, and occasionally as
cysts (deep pimples, boils).

You can do a lot to treat your acne using products available at a drugstore or cosmetic counter that do not require a prescription. However, for tougher cases of acne, you should consult a physician for treatment options.

What...

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BenzaClin

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BenzaClin® Topical Gel
(clindamycin - benzoyl peroxide) Gel

Topical Gel: clindamycin (1%) as clindamycin phosphate, benzoyl peroxide (5%) For Dermatological Use Only - Not for Ophthalmic Use

*Reconstitute Before Dispensing*

DRUG DESCRIPTION

BenzaClin® Topical Gel (clindamycin and benzoyl peroxide) contains clindamycin phosphate, (7(S)-chloro-7deoxylincomycin-2-phosphate). Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

Chemically, clindamycin phosphate is (C₁₈H₃₄ClN₂O₈PS). The structural formula for clindamycin is represented below:

Clindamycin phosphate Structural Formula Illustration

Clindamycin phosphate has molecular weight of 504.97 and its chemical name is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans- 4-propyl-L-2-pyrrolidinecarboxamido) - 1-thio-L- threo-alpha-D- galacto-octopyranoside 2-(dihydrogen phosphate).

BenzaClin (clindamycin and benzoyl peroxide) Topical Gel also contains benzoyl peroxide, for topical use. Chemically, benzoyl peroxide is (C₁₄H₁₀O₄). It has the following structural formula:

Benzoyl peroxide Structural Formula Illustration

Benzoyl peroxide has a molecular weight of 242.23.

Each gram of BenzaClin (clindamycin and benzoyl peroxide) Topical Gel contains, as dispensed, 10 mg (1%) clindamycin as phosphate and 50 mg (5%) benzoyl peroxide in a base of carbomer, sodium hydroxide, dioctyl sodium sulfosuccinate, and purified water.

What are the possible side effects of benzoyl peroxide and clindamycin topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have any of these serious side effects:

severe redness, burning, stinging, or peeling of treat skin areas; or
diarrhea that is watery or bloody.

Less serious side effects may include:

mild burning or stinging;
itching or tingly...

Read All Potential Side Effects and See Pictures of BenzaClin »

What are the precautions when taking clindamycin and benzoyl peroxide (BenzaClin)?

Before using this medication, tell your doctor or pharmacist if you are allergic to benzoyl peroxide; or to clindamycin; or to lincomycin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: intestinal disorders (e.g., regional enteritis, ulcerative colitis, antibiotic-associated colitis, Clostridium difficile-associated diarrhea).

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when...

Read All Potential Precautions of BenzaClin »

Last reviewed on RxList: 7/7/2009
This monograph has been modified to include the generic and brand name in many instances.