May 24, 2017
Recommended Topic Related To:


"The U.S. Food and Drug Administration today approved Differin Gel 0.1% (adapalene), a once-daily topical gel for the over-the-counter (OTC) treatment of acne. Differin Gel 0.1% is approved for use in people 12 years of age and older.




Side Effects


During clinical trials, the most frequently reported adverse event in the BenzaClin (clindamycin and benzoyl peroxide) treatment group was dry skin (12%). The Table below lists local adverse events reported by at least 1% of patients in the BenzaClin (clindamycin and benzoyl peroxide) and vehicle groups.

Local Adverse Events - all causalities in > /= 1% of patients

n = 420
n = 168
Application site reaction 13 (3%) 1 ( < 1%)
Dry skin 50 (12%) 10 (6%)
Pruritus 8 (2%) 1 ( < 1%)
Peeling 9 (2%) -
Erythema 6 (1%) 1 ( < 1%)
Sunburn 5 (1%) -

The actual incidence of dry skin might have been greater were it not for the use of a moisturizer in these studies.

Anaphylaxis, as well as allergic reactions leading to hospitalization, have been reported during post-marketing use of clindamycin/benzoyl peroxide products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the BenzaClin (clindamycin and benzoyl peroxide) Side Effects Center for a complete guide to possible side effects


No information provided.

Read the BenzaClin Drug Interactions Center for a complete guide to possible interactions

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/28/2017

Side Effects

BenzaClin - User Reviews

BenzaClin User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication BenzaClin sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.