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Besivance

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Besivance

Besivance®
(besifloxacin) Ophthalmic Suspension

DRUG DESCRIPTION

Besivance® (besifloxacin) Ophthalmic Suspension 0.6%, is a sterile ophthalmic suspension of besifloxacin formulated with DuraSite®* (polycarbophil, edetate disodium dihydrate and sodium chloride). Each mL of Besivance® contains 6.63 mg besifloxacin hydrochloride equivalent to 6 mg besifloxacin base. It is an 8-chloro fluoroquinolone anti-infective for topical ophthalmic use.

Besivance® (besifloxacin) Structural Formula Illustration

C19H21ClFN3O3•HCl

Mol Wt 430.30

Chemical Name: (+)-7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1- cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride.

Besifloxacin hydrochloride is a white to pale yellowish-white powder.

Each mL Contains:

Active: besifloxacin 0.6% (6 mg/mL); Preservative: benzalkonium chloride 0.01%

Inactives: polycarbophil, mannitol, poloxamer 407, sodium chloride, edetate disodium dihydrate, sodium hydroxide and water for injection.

Besivance® is an isotonic suspension with an osmolality of approximately 290 mOsm/kg.

What are the possible side effects of besifloxacin ophthalmic (Besivance)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • drainage or crusting of your eye;
  • severe eye irritation after using the eye drops;
  • feeling like there is something in your eye;
  • severe eye redness or swelling; or
  • fever, or any signs of a new infection.

Less serious side effects may include:

  • eye redness or pain;
  • itchy...

Read All Potential Side Effects and See Pictures of Besivance »

What are the precautions when taking besifloxacin ophthalmic suspension (Besivance)?

Before using besifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (such as ciprofloxacin, norfloxacin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly...

Read All Potential Precautions of Besivance »

Last reviewed on RxList: 10/26/2012
This monograph has been modified to include the generic and brand name in many instances.

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Besivance - User Reviews

Besivance User Reviews

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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