Besivance (Besifloxacin Ophthalmic Suspension) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

Besivance

Blepharitis »

What is blepharitis?

Blepharitis is the medical term for inflammation of the eyelids. The word "blepharitis" is derived from the Greek word blepharos, which means "eyelid," and the Greek suffix itis, which is typically used to denote an inflammation in English. Inflammation is a general term used to describe the process by which white blood cells and chemicals produced in the body protect us from foreign substances, injury, or infection. The normal body response of inflammation involves varying degrees of swelling, redness, pain, warmth, and change in function. Blepharitis is an inflammation of the eyelids, causing red, irritated, itchy eyelids, and the formation of dandruff-like scales on the eyelashes. It is a very common eye disorder with a wide variety of causes. It affects people of all ages. Although it may be uncomfortable, annoying, or unattractive, blepharitis ...

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Besivance

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Besivance™
(besifloxacin) Ophthalmic Suspension 0.6% Sterile Topical Ophthalmic Drops

DRUG DESCRIPTION

Besivance™ (besifloxacin ophthalmic suspension) 0.6%, is a sterile ophthalmic suspension of besifloxacin formulated with DuraSite®* (polycarbophil, edetate disodium dihydrate and sodium chloride). Each mL of Besivance™ contains 6.63 mg besifloxacin hydrochloride equivalent to 6 mg besifloxacin base. It is an 8-chloro fluoroquinolone anti-infective for topical ophthalmic use.

Besivance™
(besifloxacin) Structural Formula Illustration

C₁₉H₂₁CIFN₃O₃•HCI
Mol Wt 430.30

Chemical Name: (+)-7-[(3R)-3-aminohexahydro-1 H-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4- oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride.

Besifloxacin hydrochloride is a white to pale yellowish-white powder.

Each mL Contains:

Active: besifloxacin 0.6% (6 mg/mL);

Preservative: benzalkonium chloride 0.01%

Inactives: polycarbophil, mannitol, poloxamer 407, sodium chloride, edetate disodium dihydrate, sodium hydroxide and water for injection.

Besivance™ (besifloxacin ophthalmic suspension) is an isotonic suspension with an osmolality of approximately 290 mOsm/kg.

What are the possible side effects of besifloxacin ophthalmic (Besivance)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

drainage or crusting of your eye;
severe eye irritation after using the eye drops;
feeling like there is something in your eye;
severe eye redness or swelling; or
fever, or any signs of a new infection.

Less serious side...

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What are the precautions when taking besifloxacin ophthalmic suspension (Besivance)?

Before using besifloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (such as ciprofloxacin, norfloxacin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only when clearly...

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Last reviewed on RxList: 6/11/2009
This monograph has been modified to include the generic and brand name in many instances.