Betaxolol Hydrochloride Ophthalmic (Betaxolol Hydrochloride) Drug Information: Overdosage and Contraindications

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May 25, 2012

Betaxolol Hydrochloride Ophthalmic

Glaucoma »

What is glaucoma?

Glaucoma is a disease of the major nerve of vision, called the optic nerve. The optic nerve receives light-generated nerve impulses from the retina and transmits these to the brain, where we recognize those electrical signals as vision. Glaucoma is characterized by a particular pattern of progressive damage to the optic nerve that generally begins with a subtle loss of side vision (peripheral vision). If glaucoma is not diagnosed and treated, it can progress to loss of central vision and blindness.

Glaucoma is usually, but not always, associated with elevated pressure in the eye (intraocular pressure). Generally, it is this elevated eye pressure that leads to damage of the eye (optic) nerve. In some cases, glaucoma may occur in the presence of normal eye pressure. This form of glaucoma is believed to be caused by poor regulation of blood flow to the optic nerve.

How common is glaucoma?

Worldwide, glaucoma...

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Betaxolol Hydrochloride Ophthalmic

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OVERDOSE

No information is available on overdosage of humans. The oral LD₅₀ of the drug ranged from 350-920 mg/kg in mice and 860-1050 mg/kg in rats. The symptoms which might be expected with an overdose of a systemically administered beta-1-adrenergic receptor blocker agent are bradycardia, hypotension and acute cardiac failure. A topical overdose of Betaxolol Hydrochloride Ophthalmic Solution may be flushed from the eye(s) with warm tap water.

CONTRAINDICATIONS

Hypersensitivity to any component of this product. Betaxolol Hydrochloride Ophthalmic Solution (betaxolol hydrochloride) is contraindicated in patients with sinus bradycardia, greater than a first degree atrioventricular block, cardiogenic shock, or patients with overt cardiac failure.

Last reviewed on RxList: 4/12/2006
This monograph has been modified to include the generic and brand name in many instances.