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Bethkis

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Bethkis

BETHKIS®
(tobramycin) Inhalation Solution

DRUG DESCRIPTION

BETHKIS is a sterile, clear, colorless to pale yellow, non-pyrogenic, aqueous solution with pH and salinity adjusted. BETHKIS is administered by a compressed air driven reusable nebulizer. The chemical formula for tobramycin is C18H37N5O9 and the molecular weight is 467.52. Tobramycin is O-3-amino-3-deoxy-α-D-glucopyranosyl(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxyL-streptamine. The structural formula for tobramycin is:

BETHKIS® (Tobramycin) Structural Formula Illustration

Each single-use 4 mL ampule of BETHKIS contains one 300 mg dose of tobramycin, with sodium chloride and sulfuric acid in water for injection. Sulfuric acid and sodium hydroxide are used to adjust the pH, as needed, to 5.0. Nitrogen is used for sparging, filling and pouching. The formulation contains no preservatives. BETHKIS does not comply with the USP with regard to pH, absorbance and osmolality.

Last reviewed on RxList: 10/26/2012
This monograph has been modified to include the generic and brand name in many instances.

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