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Betimol

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Betimol

BETIMOL®
(timolol) Ophthalmic Solution

Betimol

DRUG DESCRIPTION

Betimol® (timolol ophthalmic solution), 0.25% and 0.5%, is a non-selective beta-adrenergic antagonist for ophthalmic use. The chemical name of the active ingredient is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol. Timolol hemihydrate is the levo isomer. Specific rotation is [α]25 405nm=-16° (C=10% as the hemihydrate form in 1N HCI).

The molecular formula of timolol is Formula C13H24N4O3S and its structural formula is:

BETIMOL® (timolol) Structural Formula Illustration

Timolol (as the hemihydrate) is a white, odorless, crystalline powder which is slightly soluble in water and freely soluble in ethanol. Timolol hemihy-drate is stable at room temperature.

Betimol® (timolol ophthalmic solution) is a clear, colorless, isotonic, sterile, microbiologically preserved phosphate buffered aqueous solution. It is supplied in two dosage strengths, 0.25% and 0.5%.

Each mL of Betimol® 0.25% contains 2.56 mg of timolol hemihydrate equivalent to 2.5 mg timolol.

Each mL of Betimol® 0.5% contains 5.12 mg of timolol hemihydrate equivalent to 5.0 mg timolol.

Inactive ingredients: monosodium and disodium phosphate dihydrate to adjust pH (6.5 - 7.5) and water for injection, benzalkonium chloride 0.01% added as preservative.

The osmolality of Betimol® (timolol ophthalmic solution) is 260 to 320 mOsmol/kg.

What are the possible side effects of timolol ophthalmic?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • swelling or redness of your eyelids;
  • eye redness, discomfort, or sensitivity to light;
  • drainage, crusting, or oozing of your eyes or eyelids;
  • depressed mood, confusion, hallucinations, unusual thoughts or behavior;
  • wheezing, gasping, or other breathing problems;
  • swelling,...

Read All Potential Side Effects and See Pictures of Betimol »

Last reviewed on RxList: 3/26/2009
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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