Bexxar (Tositumomab and Iodine 1131 Tositumomab) Drug Information: Overdosage and Contraindications

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May 25, 2012

Bexxar

Non-Hodgkin's Lymphoma »

Non-Hodgkin's lymphoma facts

NHL is a cancer that originates in the lymphatic system.
About 66,000 patients are diagnosed yearly, and approximately 18,000 patients die of NHL yearly in the U.S.
There are several subtypes of NHL, each requiring different treatments.
Symptoms include swollen lymph nodes, weight loss, fever, and night sweats.
NHL is staged on a 1-4 scale with A (no associated symptoms like fever, weight loss, or night sweats) and B subtypes.
Staging the cancer is important to determine treatment and predict the outcome of treatment.
Depending on the stage and type of NHL, treatment can include chemotherapy, biological therapy, stem cell transplant, and/or radiation therapy.

What is non-Hodgkin's lymphoma?

Non-Hodgkin's lymphoma is a type of cancer that originates in the lymphatic system. It is estimated to be the sixth most common cancer in the Unite...

Read the Non-Hodgkin's Lymphoma article »

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OVERDOSE

The maximum radiation activity of the I-131 component of the BEXXAR therapeutic regimen, administered to 4 patients, were doses calculated to deliver between 85 cGy and 88 cGy total body irradiation. The incidence of NCI Grade 4 cytopenias was increased in these 4 patients compared to patients who received the recommended therapeutic dose for the BEXXAR therapeutic regimen.