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Bexxar Patient Information including If I Miss a Dose

What happens if I miss a dose (Bexxar)?

Because you will receive tositumomab in a clinical setting, you are not likely to miss a dose.

What happens if I overdose (Bexxar)?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving tositumomab (Bexxar)?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using tositumomab. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine. Ask your doctor how long after your treatment you should wait before receiving any vaccines.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Avoid handling any of your body fluids without wearing latex rubber gloves. If another person is handling your fluids (vomit, stools, or urine), they should wear gloves, eye protection, and a mask to cover the nose and mouth.

When cleaning any spills of bodily fluid, use only disposable cleaning cloths that can be flushed down a toilet. Ask your doctor or health department how to dispose of any bodily fluid spills that cannot be flushed down a toilet.

To protect others from exposure to the radioactive matter in your body, try to stay at least 6 feet away from other people, especially children or pregnant women. Follow these steps for several days after your tositumomab treatment ends:

  • Avoid crowds and public places.
  • Avoid traveling on long trips.
  • Do not share a bed or bathroom with another person.
  • Sit on the toilet while urinating and flush 3 times with the lid down after use.
  • Always wash your hands after using the bathroom.
  • Do not share a towel, wash cloth, or toothbrush with another person.
  • Do not share drinking glasses, plates, or silverware.
  • Wait at least 1 week before washing any of the clothing and bed or bath linens you have used during the week after your treatment. Keep these items separate from the laundry of other people in your home.
  • Wash your clothing and other items separately from other laundry in your home.

What other drugs will affect tositumomab (Bexxar)?

Before receiving tositumomab, tell your doctor if you are using any type of blood thinner or medication used to prevent blood clots, such as:

  • aspirin;
  • warfarin (Coumadin, Jantoven);
  • abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), rivaroxaban (Xarelto), ticlopidine (Ticlid), tirofiban (Aggrastat);
  • argatroban (Acova), dabigatran (Pradaxa), bivalirudin (Angiomax), lepirudin (Refludan);
  • dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep); or
  • alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase).

This list is not complete and other drugs may interact with tositumomab. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about tositumomab.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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