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Biaxin, Biaxin XL
Overdosage of BIAXIN can cause gastrointestinal symptoms such as abdominal pain, vomiting, nausea, and diarrhea.
Treat adverse reactions accompanying overdosage by the prompt elimination of unabsorbed drug and supportive measures. As with other macrolides, BIAXIN serum concentrations are not expected to be appreciably affected by hemodialysis or peritoneal dialysis.
Concomitant administration of BIAXIN with cisapride and pimozide is contraindicated [see DRUG INTERACTIONS].
There have been postmarketing reports of drug interactions when clarithromycin is coadministered with cisapride or pimozide, resulting in cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) most likely due to inhibition of metabolism of these drugs by BIAXIN. Fatalities have been reported.
Cholestatic Jaundice/Hepatic Dysfunction
BIAXIN is contraindicated in patients with a history of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin.
Concomitant administration of BIAXIN and colchicine is contraindicated in patients with renal or hepatic impairment.
HMG-CoA Reductase Inhibitors
Do not use BIAXIN concomitantly with HMG-CoA reductase inhibitors (statins) that are extensively metabolized by CYP3A4 (lovastatin or simvastatin), due to the increased risk of myopathy, including rhabdomyolysis [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].
Concomitant administration of clarithromycin and ergotamine or dihydroergotamine is contraindicated [see DRUG INTERACTIONS].
Contraindications For Co-administered Drugs
For information about contraindications of other drugs indicated in combination with BIAXIN, refer to their full prescribing information (contraindications section).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/28/2016
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