Recommended Topic Related To:

Bicillin C-R 900 300

"A unique type of poster placed in exam rooms helped reduce unnecessary antibiotic prescriptions for respiratory infections during flu season. The approach could help reduce costs and extend the usefulness of these drugs.

Antibiotics a"...

Bicillin C-R 900/300

Bicillin® C-R 900/300
(penicillin G benzathine and penicillin G procaine) Injectable Suspension

2 mL Syringe for deep IM injection only

Bicillin C-R 900/300

WARNING

NOT FOR INTRAVENOUS USE. DO NOT INJECT INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. THERE HAVE BEEN REPORTS OF INADVERTENT INTRAVENOUS ADMINISTRATION OF PENICILLIN G BENZA-THINE WHICH HAS BEEN ASSOCIATED WITH CARDIORESPIRATORY ARREST AND DEATH. Prior to administration of this drug, carefully read the WARNINGS, ADVERSE REACTIONS, and DOSAGE AND ADMINISTRATION sections of the labeling.

DRUG DESCRIPTION

Bicillin C-R 900/300 (penicillin G benzathine and penicillin G procaine injectable suspension) contains the equivalent of 900, 000 units of penicillin G as the benzathine and 300, 000 units of penicillin G as the procaine salts. It is available for deep intramuscular injection.

Penicillin G benzathine is prepared by the reaction of dibenzyleth-ylene diamine with two molecules of penicillin G. It is chemically designated as (2S, 5R, 6R)-3, 3-Dimethyl-7-oxo-6-(2-phenylac-etamido)-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic acid compound with N, N'-dibenzylethylenediamine (2:1), tetrahydrate. It occurs as a white, crystalline powder and is very slightly soluble in water and sparingly soluble in alcohol. Its chemical structure is as follows:

Penicillin G benzathine Structural Formula Illustration

Penicillin G procaine, (2S, 5R, 6R)-3, 3-Dimethyl-7-oxo-6-(2-pheny-lacetamido)-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic acid compound with 2-(diethylamino)ethyl p-aminobenzoate (1:1) monohydrate, is an equimolar salt of procaine and penicillin G. It occurs as white crystals or a white, microcrystalline powder and is slightly soluble in water.

Its chemical structure is as follows:

Penicillin G procaine Structural Formula Illustration

Each 2 mL syringe contains the equivalent of 1, 200, 000 units of penicillin G as follows: penicillin G benzathine equivalent to 900, 000 units of penicillin G and penicillin G procaine equivalent to 300, 000 units of penicillin G in a stabilized aqueous suspension with sodium citrate buffer; and as w/v, approximately 0. 5% lecithin, 0. 55% carboxymethylcellulose, 0. 55% povidone, 0. 1% methylparaben, and 0. 01% propylparaben.

Bicillin C-R 900/300 injectable suspension is viscous and opaque. Read CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, and DOSAGE AND ADMINISTRATION sections prior to use.

What are the possible side effects of benzathine penicillin and procaine penicillin (Bicillin C-R, Bicillin C-R 900/300)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • skin rash with bruising, severe tingling, numbness, pain, muscle weakness;
  • rash or itching with swollen glands, joint pain, or general ill feeling;
  • diarrhea that is...

Read All Potential Side Effects and See Pictures of Bicillin C-R 900/300 »

What are the precautions when taking penicillin g benzathine and penicillin g procaine injection (Bicillin C-R 900/300)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or to procaine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, asthma.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

Kidney function is not fully developed in newborns/infants. This medication is removed by the kidneys. Therefore, newborns/infants may be at greater...

Read All Potential Precautions of Bicillin C-R 900/300 »

Last reviewed on RxList: 2/20/2009
This monograph has been modified to include the generic and brand name in many instances.

A A A

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Women's Health

Find out what women really need.

Related Drugs
advertisement
advertisement
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations