Bicillin C-R 900 300
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Bicillin C-R 900/300
Bicillin C-R 900/300 (penicillin g benzathine and penicillin g procaine injection) is indicated in the treatment of infections as described below that are susceptible to serum levels characteristic of this particular dosage form. Therapy should be guided by bacteriological studies (including susceptibility testing) and by clinical response.
Bicillin C-R 900/300 (penicillin g benzathine and penicillin g procaine injection) is indicated in the treatment of the following in pediatric patients:
Moderately severe to severe infections of the upper-respiratory tract, scarlet fever, erysipelas, and skin and soft-tissue infections due to susceptible streptococci.
NOTE: Streptococci in Groups A, C, G, H, L, and M are very susceptible to penicillin G. Other groups, including Group D (enterococci), are resistant. Penicillin G sodium or potassium is recommended for streptococcal infections with bacteremia. Moderately severe pneumonia and otitis media due to susceptible pneumococci.
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, peritonitis, and arthritis of pneumococcal etiology are better treated with penicillin G sodium or potassium during the acute stage.
When high, sustained serum levels are required, penicillin G sodium or potassium, either IM or IV, should be used. This drug should not be used in the treatment of venereal diseases, including syphilis, gonorrhea, yaws, bejel, and pinta.
DOSAGE AND ADMINISTRATION
Group A infections of the upper-respiratory tract, skin and soft-tis-sue infections, scarlet fever, and erysipelas: A single injection of Bicillin C-R 900/300 (penicillin g benzathine and penicillin g procaine injection) is usually sufficient for the treatment of Group A streptococcal infections in pediatric patients.
Pneumococcal Infections (except pneumococcal meningitis)
One Bicillin C-R 900/300 (penicillin g benzathine and penicillin g procaine injection) repeated at 2- or 3-day intervals until the temperature is normal for 48 hours. Other forms of penicillin may be necessary for severe cases.
Method of Administration
Bicillin C-R is intended for Intramuscular Injection ONLY. Do not inject into or near an artery or nerve, or intravenously or admix with other intravenous solutions. (See WARNINGS section). Administer by DEEP INTRAMUSCULAR INJECTION in the upper, outer quadrant of the buttock. In neonates, infants and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site.
Because of the high concentration of suspended material in this product, the needle may be blocked if the injection is not made at a slow, steady rate.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Bicillin‚ C-R 900/300 (penicillin G benzathine and penicillin G procaine injectable suspension) is supplied in 2 mL size syringes in packages of 10 syringes as follows:
1, 200, 000 units per syringe (21 gauge, thin-wall 1 inch needle for pediatric use), NDC 60793-602-10.
Store in a refrigerator, 2° to 8°C (36° to 46°F).
Keep from freezing.
Prescribing Information as of December 2006. Manufactured and Distributed by: King Pharmaceuticals, Inc., Bristol, TN 37620
Last reviewed on RxList: 2/20/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Bicillin C-R 900/300 Information
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