Bicillin L-A Inj / Tubex
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Bicillin L-A Injectable in Tubex
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin LA and other antibacterial drugs, Bicillin L-A should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Intramuscular penicillin G benzathine is indicated in the treatment of infections due to penicillin-G-sensitive microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.
The following infections will usually respond to adequate dosage of intramuscular penicillin G benzathine:
Mild-to-moderate infections of the upper-respiratory tract due to susceptible streptococci.
Medical Conditions in which Penicillin G Benzathine Therapy is indicated as Prophylaxis:
Rheumatic fever and/or chorea—Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions. It has also been used as follow-up prophylactic therapy for rheumatic heart disease and acute glomerulonephritis.
DOSAGE AND ADMINISTRATION
Streptococcal (Group A) Upper Respiratory Infections (for example, pharyngitis)
Adults - a single injection of 1,200,000 units; older pediatric patients—a single injection of 900,000 units; infants and pediatric patients under 60 lbs.—300,000 to 600,000 units.
Primary, secondary, and latent—2,400,000 units (1 dose). Late (tertiary and neurosyphilis)— 2,400,000 units at 7-day intervals for three doses. Congenital—under 2 years of age: 50,000 units/kg/body weight; ages 2 to 12 years: adjust dosage based on adult dosage schedule.
Yaws, Bejel, and Pinta - 1,200,000 units (1 injection).
Prophylaxis - for rheumatic fever and glomerulonephritis. Following an acute attack, penicillin G benzathine (parenteral) may be given in doses of 1,200,000 units once a month or 600,000 units every 2 weeks.
Method Of Administration
BICILLIN L-A IS INTENDED FOR INTRAMUSCULAR INJECTION ONLY. DO NOT INJECT INTO OR NEAR AN ARTERY OR NERVE, OR INTRAVENOUSLY OR ADMIX WITH OTHER INTRAVENOUS SOLUTIONS. (SEE WARNINGS SECTION.)
Administer by DEEP INTRAMUSCULAR INJECTION in the upper, outer quadrant of the buttock (dorsogluteal) or the anterolateral thigh (ventrogluteal). In neonates, infants and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site.
Because of the high concentration of suspended material in this product, the needle may be blocked if the injection is not made at a slow, steady rate.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Bicillin L-A (penicillin G benzathine injectable suspension) is supplied in packages of 10 disposable syringes as follows:
1 mL size, containing 600,000 units per syringe, (21 gauge, thin-wall 1 inch needle for pediatric use), NDC 60793-700-10.
2 mL size, containing 1,200,000 units per syringe, (21 gauge, thin-wall 1-½ inch needle), NDC 60793-701-10.
4 mL size, containing 2,400,000 units per syringe (18 gauge x 1–½ inch needle), NDC 60793702-10.
Store in a refrigerator, 2° to 8°C (36° to 46°F).
Keep from freezing.
Distributed by: Pfizer Inc., New York, NY 10017. Revised: October 2015This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 10/29/2015
Additional Bicillin L-A Injectable in Tubex Information
- Bicillin L-A Injectable in Tubex Drug Interactions Center: penicillin g benzathine im
- Bicillin L-A Injectable in Tubex Side Effects Center
- Bicillin L-A Injectable in Tubex in detail including Side Effects and Drug Images
- Bicillin L-A Injectable in Tubex Overview including Precautions
- Bicillin L-A Injectable in Tubex FDA Approved Prescribing Information including Dosage
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