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Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. Prnicillin G benzathin is prepared by the reaction of dibenzylethylene diamine with two molecules of penicillin G. It is chemically designated as (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compound with N,N'-dibenzylethylenediamine (2:1), tetrahydrate. It occurs as a white, crystalline powder and is very slightly soluble in water and sparingly soluble in alcohol. Its chemical structure is as follows:

Bicillin L-A contains penicillin G benzathine in aqueous suspension with sodium citrate buffer and, as w/v, approximately 0.5% lecithin, 0.6% carboxymethylcellulose, 0.6% povidone, 0.1% methylparaben, and 0.01% propylparaben.

Bicillin L-A injectable suspension in TUBEX® formulation is viscous and opaque. It is available in 1 mL and 2 mL TUBEX® Sterile Cartridge-Needle Units containing the equivalent of 600,000 units and 1,200,000 units respectively of penicillin G as the benzathine salt. Read CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, and DOSAGE AND ADMINISTRATION sections prior to use.

Last reviewed on RxList: 3/2/2009
This monograph has been modified to include the generic and brand name in many instances.