Bicillin L-A Inj / Tubex
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Bicillin L-A Injectable in Tubex
As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy, asthma, hay fever, or urticaria.
As with other treatments for syphilis, the Jarisch-Herxheimer reaction has been reported.
The following have been reported with parenteral penicillin G:
General: Hypersensitivity reactions including the following: skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia; other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration); and anaphylaxis including shock and death. Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, penicillin G should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to therapy with penicillin G. Serious anaphylactic reactions require immediate emergency treatment with epinephrine. Oxygen, intravenous steroids, and airway management, including intubation, should also be administered as indicated.
The following adverse events have been temporally associated with parenteral administration of penicillin G benzathine:
Gastrointestinal: Nausea, vomiting; blood in stool; intestinal necrosis.
Hemic and Lymphatic: Lymphadenopathy.
Injection Site: Injection site reactions including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage.
Nervous System: Nervousness; tremors; dizziness; somnolence; confusion; anxiety; euphoria; transverse myelitis; seizures; coma. A syndrome manifested by a variety of CNS symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne's syndrome), has been reported after administration of penicillin G procaine and, less commonly, after injection of the combination of penicillin G benzathine and penicillin G procaine. Other symptoms associated with this syndrome, such as psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and/or abnormal perception in taste, also may occur.
Special Senses: Blurred vision; blindness.
Read the Bicillin L-A Injectable in Tubex (penicillin g benzathine injectable in tubex) Side Effects Center for a complete guide to possible side effects
Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin, and concurrent use of these drugs should be avoided.
Concurrent administration of penicillin and probenecid increases and prolongs serum penicillin levels by decreasing the apparent volume of distribution and slowing the rate of excretion by competitively inhibiting renal tubular secretion of penicillin.
Read the Bicillin L-A Injectable in Tubex Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 10/29/2015
Additional Bicillin L-A Injectable in Tubex Information
- Bicillin L-A Injectable in Tubex Drug Interactions Center: penicillin g benzathine im
- Bicillin L-A Injectable in Tubex Side Effects Center
- Bicillin L-A Injectable in Tubex in detail including Side Effects and Drug Images
- Bicillin L-A Injectable in Tubex Overview including Precautions
- Bicillin L-A Injectable in Tubex FDA Approved Prescribing Information including Dosage
Bicillin L-A Injectable in Tubex - User Reviews
Bicillin L-A Injectable in Tubex User Reviews
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