"The latest results for single-agent ibrutinib (Imbruvica, Pharmacyclics and Janssen) in patients with refractory Waldenström's macroglobulinemia show that the drug is highly active and has a good risk-benefit ratio in patients for whom mul"...
Mechanism Of Action
The mechanism of action of carmustine is not fully understood. While carmustine alkylates DNA and RNA, it is not cross-resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins. The metabolites may contribute to antitumor activity and toxicities of carmustine.
The exposure-response relationship for efficacy or safety is unknown.
Following a short intravenous infusion, the reported elimination half-life ranges from 15 minutes to 75 minutes.
Carmustine may be inactivated through denitrosation reactions catalyzed by both cytosolic and microsomal enzymes, including NADPH and glutathione-S-transferase.
Approximately 60% to 70% of a total dose is excreted in the urine within 96 hours. Approximately 10% is eliminated as respiratory CO2.
Last reviewed on RxList: 4/11/2017
This monograph has been modified to include the generic and brand name in many instances.
Additional BiCNU Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get the latest treatment options.