"The latest results for single-agent ibrutinib (Imbruvica, Pharmacyclics and Janssen) in patients with refractory Waldenström's macroglobulinemia show that the drug is highly active and has a good risk-benefit ratio in patients for whom mul"...
The following serious adverse reactions are described elsewhere in the labeling:
- Myelosuppression [see WARNINGS AND PRECAUTIONS
- Pulmonary toxicity [see WARNINGS AND PRECAUTIONS
- Administration Reactions [see WARNINGS AND PRECAUTIONS
- Carcinogenicity [see WARNINGS AND PRECAUTIONS
- Ocular Toxicity [see WARNINGS AND PRECAUTIONS
The following adverse reactions associated with the use of BiCNU were identified in clinical studies or postmarketing reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Tachycardia and chest pain.
Nausea, vomiting, anorexia, and diarrhea
Increased transaminase, increased alkaline phosphatase, increased bilirubin levels
Infections And Infestations
Opportunistic infection (including with fatal outcome).
Neoplasms Benign, Malignant And Unspecified (Including Cysts And polyps)
Progressive azotemia, decrease in kidney size, renal failure
Nervous System Disorders
Headaches, encephalopathy, and seizures
Pneumonitis, interstitial lung disease
Reproductive System And Breast Disorders
Skin And Subcutaneous Tissue Disorders
Read the BiCNU (carmustine) Side Effects Center for a complete guide to possible side effects
Effects Of Other Drugs On BiCNU
Phenobarbital induces the metabolism of carmustine and may compromise antitumor activity of BiCNU. Consider alternative drugs to phenobarbital.
Effects Of BiCNU On Other Drugs
BiCNU when coadministered with phenytoin may reduce phenytoin serum concentrations. Consider alternative drugs to phenytoin.
Read the BiCNU Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 4/11/2017
Additional BiCNU Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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